Phylogenetic analysis traces CRF01_AE’s decades-long spread across Asia
Bayesian phylogeographic analysis links CRF01_AE’s spread from Central Africa through Thailand and across Asia to repeated cross-border movements and prolonged ...
Tag: HIV-1
Review maps cell-specific MAVS and inflammasome signaling in HIV-1
A review finds that HIV-1 suppresses MAVS-dependent antiviral signaling in myeloid cells while distinct IFI16 and CARD8 pathways can promote ...
Research report: HIV-1 Vpr: a multifunctional accessory protein with potential contributions to AIDS pathogenesis and persistence
A 2026 review concludes that HIV-1 accessory protein Vpr coordinates cell-cycle arrest, mitochondrial death, immune signaling and viral replication, but ...
Defective HIV proviruses reprogram T cells at selected integration sites
A cellular study shows how transcriptionally active defective HIV proviruses can reprogram CD4 T cells through integration-site-specific effects on host ...
sncRNA signatures underlying HIV-1 restriction in elite controllers
A comparative CD4+ T-cell study linked elite control of HIV-1 to reduced miR-99b-5p and miR-125a-5p, whose inhibition modestly reduced viral ...
AI-Designed Molecules Show Promise as Host-Directed Antiviral Hits Against DHPS
Korea University researchers used benchmarked AI models to design small-molecule fragments that experimentally inhibited the human enzyme DHPS, a host ...
Two-Drug HIV Therapy Reaches Lymph Node Reservoirs, Trial Imaging Shows
A randomized trial combining in situ viral imaging and mass spectrometry shows that first-line dolutegravir/lamivudine therapy penetrates lymph node tissue ...
Cryptococcal Meningitis Reshapes HIV-1 Populations in the Brain
A study of people with HIV-1 and cryptococcal meningitis reveals diverse mechanisms shaping viral populations in the central nervous system, ...
Beyond BRD4: Bromodomain Protein BRD9 Emerges as a New Regulator of Retroviral Latency
A new review highlights how the bromodomain protein BRD9, a core component of the ncBAF chromatin-remodeling complex, has emerged as ...
How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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