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Cancer
First clinical trials set for MRI cancer detection
Case Western Reserve University-developed imaging agent for MRI prostate cancer detection gets FDA approval for safety trials, set to begin in May in ColumbusCredit: Case Western Reserve University CLEVELAND--The U.S. Food and Drug…
Less is more for the next generation of CAR T cells
Shorter "linkers" on CARs may expand use for patients with acute leukemia PHILADELPHIA--When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric…
Sculpting radiation beam spares lung cancer patients from severe, disabling complication
Despite receiving high radiation doses to their tumors, lung cancer patients treated with technique that spares a large part of the esophagus did not develop severe inflammation of the esophagus. BOSTON - For many patients with localized…
Study finds stereotactic body radiotherapy is safe for treating multiple metastases
A phase 1 clinical trial led by investigators at the University of Chicago Medicine testing the effects of stereotactic body radiotherapy for treating multiple metastases has determined that treatments used for single tumors can also be…
New research data on the regulation of hormone-dependent breast cancer
Notch proteins are key regulators of growth and differentiation of both normal and cancer cells. Researchers in Turku, Finland, have now demonstrated that the activities of distinct Notch family members are modified differently by…
A new study identifies interleukin 11 as a marker of cancer-associated fibroblasts
Interleukin 11-producing fibroblasts are potential candidates for new therapeutic targets in human colorectal cancerCredit: Hiroyasu Nakano IL-11 is known to promote the development of colorectal cancer in humans and mice, but when…
New therapy target for malignant melanomas in dogs
Credit: Naoya Maekawa, et al. npj Precision Oncology. February 12, 2021 Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.…
Novel agent shows promise in treating the most aggressive type of breast cancer
A global clinical study confirms the effectiveness of targeted antibody drug conjugates against refractory metastatic triple-negative breast cancer BOSTON - A unique antibody drug conjugate (ADC), which delivers a high dose of a…
Grant aims to reduce prostate cancer disparities among black men
$250,000 grant funded by Pfizer Global Medical Grants and overseen by the American Cancer Society is Aimed at Reducing Gaps in Care and Barriers to TreatmentCredit: Henry Ford Health System DETROIT - Henry Ford Cancer Institute has…
Study models economic impact of proposed law to regulate high-risk diagnostic tests
Potential impact to health care costs will depend on key details in the bill's final language. BOSTON - Legislation currently under consideration in the U.S. Congress would increase regulatory oversight of certain diagnostic tests, and a…
Higher mushroom consumption is associated with a lower risk of cancer
HERSHEY, Pa. -- Next time you make a salad, you might want to consider adding mushrooms to it. That's because higher mushroom consumption is associated with a lower risk of cancer, according to a new Penn State study, published on March…
Insurance isn’t enough for women at high risk of breast cancer
Financial obstacles create barriers for many women Women at high risk of breast cancer face cost-associated barriers to care even when they have health insurance, a new study has found. The findings suggest the need for more transparency…
Ingredient in Indian long pepper shows promise against brain cancer in animal models
Penn scientists use cryo-electron microscopy to illuminate how piperlongumine works against glioblastoma PHILADELPHIA--Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous…
First of its kind study links wildfire smoke to skin disease
Wildfire smoke can trigger a host of respiratory and cardiovascular symptoms, ranging from runny nose and cough to a potentially life-threatening heart attack or stroke. A new study suggests that the dangers posed by wildfire smoke may…
New liquid biopsy test to ID lymph node metastasis in early-stage T1 colorectal cancer
This new, blood-based test successfully identifies individuals with lymph node metastasis associated with high-risk T1 colorectal cancer and potentially could help people with non-high-risk early-stage colorectal cancer avoid unnecessary…
Esophage cancer: Discovery of the mechanisms involved
Publication in Cell Stem Cell: Researchers at the Université libre de Bruxelles, ULB uncover a new mechanism involved in the development of metaplasia in the oesophagus Metaplasia is defined as the replacement of a fully differentiated…
Research brief: Improving rug efficacy against prostate cancer and related bone growths
Published in the Advanced Functional Materials, University of Minnesota researcher Hongbo Pang led a cross-institutional study on improving the efficacy of nucleotide-based drugs against prostate cancer and bone metastasis. In this…
Mayo study finds colon cancer driven by hereditary gene mutations in 1 in 6 patients
ROCHESTER, Minn. -- A new Mayo Clinic study bolsters evidence that colorectal cancer is often imprinted in family genes and passed on from one generation to the next. In the study, published in Clinical Gastroenterology and Hepatology,…
‘Information theory’ recruited to help scientists find cancer genes
Field of mathematics devoted to how information is measured, stored and transmitted uncovers possible key gene that spurs common childhood leukemiaCredit: Kate Zvorykina (Ella Maru Studio), Design: Michael Koldobskiy and Andrew Feinberg,…
Novel drug regenerates erectile nerves damaged by prostate surgery
Credit: Lisa Baker, Ph.D./Courtesy Albert Einstein College of Medicine April 19, 2021--(BRONX, NY)--Researchers at Albert Einstein College of Medicine have developed a topical drug that regenerates and restores the function of erectile…