Biology
Phage screening identifies candidate tuberculosis peptides for HLA-E
A phage-display and computational screen prioritized 14 Mycobacterium tuberculosis fragments as candidate HLA-E ligands, but experimental validation is still required.
Epidemiological profile of HPV infection, associations with cervical lesions and vaginal microecological disorders, and nine-valent vaccine coverage in Northwest China: a 6-year retrospective study of 57,035 women
A retrospective study of 57,035 women in Shaanxi found HPV prevalence of 28.77%, persistent infection in 33.75% of those followed,...
MSIPep prioritizes tumor peptides in leukemia and solid-tumor datasets
MSIPep combines immunopeptidomics, transcriptomics and deep learning to identify and computationally prioritize candidate tumor peptides in leukemia and solid-tumor datasets.
GLIS3 regulates astrocyte differentiation in human stem cells
Experiments in mouse-derived astrocytes and human embryonic stem cells identify GLIS3 as an upstream regulator of astrocyte differentiation and neural...
Fungal parasite selects against larger yellow dung flies
A severe fungal epidemic in Swiss yellow dung flies revealed that larger adults were more susceptible to fatal infection, while...
BioSIFTR infers gut microbiome functions from shallow sequencing
BioSIFTR inferred microbial functions from shallow shotgun sequencing using biome-specific genome catalogues and outperformed similar approaches in synthetic-community and gut-microbiome...
PRKAR2A Emerges as Candidate Spatial cAMP–PKA Router in TNBC
A critical review finds that PRKAR2A is a plausible spatial regulator of cAMP–PKA signalling in triple-negative breast cancer, although current...
Molecular survey finds widespread Cryptosporidium and limited Giardia in Victorian pigs
A survey of 626 pig faecal samples from 37 Victorian farms found Cryptosporidium in 51.1% of samples and Giardia duodenalis...
Gene architecture predicts isoform diversity across four genomes
Longer introns, shorter exons and more complex gene organization were consistently associated with higher transcript-isoform diversity in humans, mice, flies...
Efficacy of statistical and design interventions for improving reproducibility in biomedical research
A registered-report simulation study found that statistical and design interventions for improving biomedical research reproducibility had mixed and measure-dependent effects.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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