Machine Learning and Proteomics Reveal Why Kidney Injury Turns Chronic
A multi-omics study of over 53,000 UK Biobank participants identifies 25 proteins, including galectin-3, that predict and may drive the ...
Tag: structural biology
Scientists Reveal Hidden Clustering Switch That Amplifies Lymphatic Vessel Growth Signals
KAIST and IBS researchers have determined the 3D structure of the VEGF-C–VEGFR-3 complex and shown that receptor clustering acts as ...
Deep-sea microbe reveals how nitrogen fixation survives near-boiling heat
Scientists have purified and structurally resolved an exceptionally heat-stable nitrogenase from a deep-sea archaeon, capturing a turnover state never before ...
Human Mitochondrial Barrel Factory Caught in Two States by Cryo-EM
Cryo-electron microscopy has revealed monomeric and interlocked dimeric structures of the human mitochondrial SAM complex, showing that a conserved beta-barrel-switching ...
Cryo-ET Captures Molecular Movie of Rotavirus Punching Into Cells
Harvard Medical School researchers used cryo-electron tomography to reveal how rotavirus VP7 forms a membrane pore that delivers the viral ...
Atomic-Scale Toolkit Reveals How Ancient Herbal Formulas Hit Multiple Targets at Once
A new review details how cryo-electron microscopy, AI modeling and time-resolved crystallography are decoding the multi-target synergy of traditional Chinese ...
Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a ...
Locked and Loaded: Structural Studies Reveal How the SCREW Peptide Engages Its NUT Receptor
Three independent structural studies reveal that the plant receptor NUT recognizes the disulfide-locked cyclic loop of SCREW phytocytokines and recruits ...
Chemical Ruler Showdown: Long Spacer Beats Cleavable Design in Protein Mapping
A systematic benchmark across sample complexities shows the non-cleavable cross-linker DSS outperforms cleavable DSSO for most cross-linking mass spectrometry experiments, ...
New Synthetic Nanobody Library Streamlines Cryo-EM Studies of Small Proteins
Researchers have engineered S1.0, a ribosome-display synthetic nanobody library that yields high-affinity binders compatible with the Legobody cryo-EM toolkit without ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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