New Dashboard Brings Protein Structure Into the Hunt for Disease-Causing Gene Variants
Researchers have developed ProtSAVI, an R-based dashboard that combines protein structure analysis with ACMG/AMP criteria to reclassify variants of uncertain ...
Tag: structural biology
Hepatitis C Vaccine Design Gains Ground as Structures Reveal How Naive Antibodies See Viral Envelope
New structural and biochemical analyses of the hepatitis C virus E2 glycoprotein show that germline-reverted broadly neutralizing antibodies recognize the ...
Cryo-EM Exposes Hidden Architecture of a Bacterial Antiviral Weapon Found in Pathogens
Cryo-electron microscopy has revealed the first structure of a TenpIN type III toxin-antitoxin complex common to several pathogenic bacteria, showing ...
Ancient Microbe Reveals a Surprising New Route to Natural Fertilizer
Saint Louis University researchers have revealed an unexpected nitrogenase supercomplex in an ancient methanogen, a structural discovery that could transform ...
Cryo-EM Captures 76 RNA Shapes at Once, Rewriting How Ribozymes Work
Researchers have resolved 76 coexisting conformers of the RNase P ribozyme at near-atomic resolution, revealing that catalysis arises from dynamic ...
Molecular Movie Captures Penicillin Being Built Atom by Atom
Using X-ray free-electron lasers, Oxford-led researchers have captured a frame-by-frame molecular movie revealing the previously unseen intermediates through which the ...
X-ray Lasers Catch Penicillin-Making Enzyme in the Act, Revealing Surprise Intermediates
Time-resolved X-ray free-electron laser crystallography has captured previously unseen intermediates in the enzyme that forges the penicillin ring system, revealing ...
Magnetic additives slash measurement times in fluorine protein NMR
Researchers have shown that adding gadolinium-based paramagnetic compounds to solid protein samples cuts fluorine-19 NMR measurement times by more than ...
Structural Analysis Reveals How H5N1 Bird Flu Hemagglutinin Could Stabilize for Human Adaptation
A computational structural analysis of H5N1 clade 2.3.4.4b hemagglutinin reveals multiple independent molecular mechanisms by which mutations could raise the ...
Graphene Reservoirs Bring Precise Ice Thickness Control to Cryo-EM
Researchers have engineered sagging graphene reservoirs that confine liquid films to precise, reproducible nanometer-scale thicknesses, solving a decades-old bottleneck in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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