Cryo-electron microscopy structures of the cyanobacterial ChlG2HliD2 complex uncover how chlorophyll synthase coordinates substrate entry, catalysis, and photoprotective pigment binding ...
Researchers have developed SRLIDP, a dual-granularity computational framework that extracts protein disorder signals across intermediate language model layers while filtering ...
Researchers have uncovered how host membrane sphingomyelin and cholesterol act synergistically as a conformational chaperone to drive Cytolysin A pore ...
Researchers developed a trapezoid cryo-FIB milling strategy combined with finite element mechanical modeling to enable dual-axis cryo-electron tomography and prevent ...
Researchers have introduced ContextMirror 2.0, an unsupervised coevolutionary algorithm that maps species-specific protein interactions and identifies functional bacterial communities without ...
A structure-guided bivalent vaccine candidate stabilizes the prefusion respiratory syncytial virus fusion protein without exogenous disulfides, eliciting durable neutralizing antibodies ...
A T271D mutant of L-Pantolactone dehydrogenase shows an 8.2-fold increase in whole-cell catalytic activity for D-pantolactone production.
A new Soft-Voting framework weights common-line evidence by confidence, lowering orientation errors on synthetic low-SNR data and yielding competitive ab ...
A compact energy-based neural network called LEEN predicts protein stability changes from single amino acid substitutions using roughly 2 to ...
Researchers have developed GraphPepTox, a geometric deep learning framework that models spatial residue relationships to improve peptide toxicity prediction.
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