Vision–language models read region names from multiple sequence alignment images accurately but fail badly at defining residue boundaries, where a...

The publication of MultimerMapper arrives at a moment when the bottleneck in computational structural biology has visibly shifted. Producing a...

A new conceptual analysis argues that property cliffs, abrupt physicochemical property changes triggered by small structural modifications, exist across acidity,...

A new multiscale web server called InRegPep generates ensembles of amyloid protofilament models that matched experimental structures within 5 angstroms...

Cryo-electron microscopy structures of the Anopheles stephensi IR8a-IR75k receptor complex reveal how carboxylic acid odorants are recognized and how binding...

Researchers have unveiled LoL-align, a probabilistic protein structure alignment algorithm that outperforms TM-align and Dali in detecting remote homologs and...

A new hybrid framework called HDOCK-Multimer combines protein-protein docking with combinatorial assembly to predict the structures of large protein complexes...

A systematic review of 38 studies finds that protein language models excel on benchmarks but largely lack experimental validation, prompting...

By swapping every valine in the protein GB1 for fluorinated analogues, researchers used fluorine-19 NMR, three-bond coupling constants and gamma...

Researchers have resolved 76 coexisting conformers of the RNase P ribozyme at near-atomic resolution, revealing that catalysis arises from dynamic...