Cryo-EM Reveals How Bacteria Switch On Their Lipopolysaccharide Transport Machine
Cryo-electron microscopy structures of the complete Lpt bridge show that a single transmembrane helix of LptC acts as a substrate-responsive...
Cryo-EM Captures the Step-by-Step Activation of the MERS-CoV Spike Protein
Time-course cryo-electron microscopy has revealed the sequence of structural changes by which DPP4 receptor binding progressively activates the MERS-CoV spike...
Magnetic additives slash measurement times in fluorine protein NMR
Researchers have shown that adding gadolinium-based paramagnetic compounds to solid protein samples cuts fluorine-19 NMR measurement times by more than...
Scientists Capture the Spliceosome in the Act of Shutting Itself Down
Cryo-electron microscopy structures of human spliceosomes reveal the sequential roles of the helicases Aquarius, DHX15 and DHX35, together with newly...
AI Reads Protein Sequences to Find Domain Boundaries Without Any Structural Data
A new machine learning framework called Seq2DomML predicts residue-level protein domain boundaries in bacterial proteins directly from sequence, outperforming established...
New Web Tool Maps the Atomic Handshakes That Decide What Proteins Do
A free interactive web server called COCaDA-web lets researchers explore the atomic contact networks of more than 240,000 proteins in...
Human Mitochondrial Barrel Factory Caught in Two States by Cryo-EM
Cryo-electron microscopy has revealed monomeric and interlocked dimeric structures of the human mitochondrial SAM complex, showing that a conserved beta-barrel-switching...
Atomic-Scale Toolkit Reveals How Ancient Herbal Formulas Hit Multiple Targets at Once
A new review details how cryo-electron microscopy, AI modeling and time-resolved crystallography are decoding the multi-target synergy of traditional Chinese...
Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a...
Chemical Ruler Showdown: Long Spacer Beats Cleavable Design in Protein Mapping
A systematic benchmark across sample complexities shows the non-cleavable cross-linker DSS outperforms cleavable DSSO for most cross-linking mass spectrometry experiments,...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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