Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a...
Chemical Ruler Showdown: Long Spacer Beats Cleavable Design in Protein Mapping
A systematic benchmark across sample complexities shows the non-cleavable cross-linker DSS outperforms cleavable DSSO for most cross-linking mass spectrometry experiments,...
New Synthetic Nanobody Library Streamlines Cryo-EM Studies of Small Proteins
Researchers have engineered S1.0, a ribosome-display synthetic nanobody library that yields high-affinity binders compatible with the Legobody cryo-EM toolkit without...
Cryo-EM Reveals How TB Drugs Target the Bacterial Cell Wall Epimerase Complex
Cryo-electron microscopy structures of the Mycobacterium tuberculosis DprE1–DprE2 epimerase complex reveal its tetrameric architecture and the precise binding modes of...
New Protein Structure Database Maps 410,000 Interactions Across Farm Animals
Researchers have launched AASIA, the first structure-informed protein interaction database covering chickens, ducks, pigs, cattle, and sheep with over 410,000...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory...
Kaggle Challenge Reveals Lessons for Particle Picking in Cryo-Electron Tomography
Cryo-electron tomography has transformed structural biology by allowing researchers to visualize molecular machinery inside cells and other complex biological environments....
Universal Pipeline Enables High-Resolution GPCR Structure Determination
G protein-coupled receptors, or GPCRs, sit at the crossroads of biology and medicine. Embedded in cell membranes, these molecular sensors...
Protein nanocrates overcome air–water interface artifacts in cryo-EM
Cryo-electron microscopy has transformed structural biology by allowing scientists to visualize proteins and other biological machines at near-atomic resolution. Yet...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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