Two Forms of the Estrogen Receptor Play Opposing Roles in Lupus Inflammation
New research shows that two splice variants of estrogen receptor alpha, ERα66 and ERα46, exert opposing, cell-type-specific and potentially sex-specific ...
Tag: microglia
APOE-Stratified Genome-Wide Study Reveals Hidden Genetic Architecture of Alzheimer’s Disease
A large APOE-stratified genome-wide association study reveals that Alzheimer's disease genetic risk variants have effects that are either amplified or ...
Stress Hits the Male and Female Hippocampus in Fundamentally Different Ways
A two-hit mouse study reveals that juvenile and adult stress reshape the male and female hippocampus through distinct behavioral, immune, ...
Ginger-Inspired Molecule 6SA Eases Depression by Targeting Brain Immune Signaling
A newly synthesized ginger-inspired TRPV1 agonist, 6SA, reverses corticosterone-induced depressive-like behavior in mice by restoring the Glul-Gm57375 signaling axis in ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
Silencing PLSCR1 Curbs Brain Inflammation and Memory Loss in Alzheimer’s Mice by Dampening the NLRP3 Inflammasome
A new study shows that silencing the protein PLSCR1 reduces inflammatory microglial activation and improves cognition in Alzheimer's model mice ...
Base Editing Corrects Gene Mutation and Slows Motor Neuron Disease in Mice
Kyoto University researchers used adenine base editing to correct the TFG mutation behind HMSN-P, delaying disease onset and extending survival ...
Brain Mosaicism Links Development, Ageing and Neurodegeneration
A new review argues that somatic mosaicism is a pervasive feature of the human brain that links development, ageing and ...
Sleep Loss Rewires How Tramadol Acts on the Adolescent Brain
A new rat study finds that sleep deprivation reshapes the neurobiological effects of tramadol in the adolescent brain, altering lipid ...
New Optical Windows Let Scientists Watch the Living Mouse Brain for Weeks
Researchers in Hong Kong systematically compared transcranial optical windows for imaging the living mouse brain, identified skull regrowth as the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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