Deleting TBK1 Entirely Slows Disease Progression in ALS Model Mice
Complete deletion of the ALS-linked gene TBK1 suppresses microglial activation and extends disease duration in SOD1-ALS model mice, a new ...
Tag: microglia
Blocking immune cell lipid signals may contain glioblastoma before surgery
VIB-KU Leuven researchers report that blocking lipid signals from brain immune cells made glioblastoma less invasive in mouse models and ...
Electroacupuncture Eases Cognitive Impairment in Schizophrenia Model Mice
A preclinical mouse study reports that electroacupuncture at the ST36 acupoint improved recognition memory over three weeks while suppressing neuroinflammation ...
TRIM11 Shields Brain Cells from Ferroptosis After Stroke by Stabilizing DUSP6
A study in Clinical and Experimental Medicine reports that TRIM11 protects microglia from oxidative stress and ferroptosis during cerebral ischemia ...
Research report: Time matters: CB2 receptor, developmental stress sensitivity and affective vulnerability
A new review synthesizes evidence that the CB2 cannabinoid receptor is dynamically remodeled by early-life and adolescent adversity in a ...
Chronic Neuropeptide S Treatment Restores Sleep and Cuts Amyloid Pathology in Alzheimer’s Mice
Chronic intracerebroventricular neuropeptide S treatment increased NREM sleep and reduced amyloid-related pathology in APP/PS1 Alzheimer's model mice, with BV2 cell ...
SIRPα promotes triple-negative breast cancer brain metastasis in models
A preclinical study found that SIRPα signaling inside triple-negative breast cancer cells promoted mitochondrial fission, motility, immune tolerance and brain ...
Aging DNA alarm links cellular stress to persistent brain inflammation
A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across several neurological disorders.
Microglial iron transport failure drives dopaminergic neuron loss in Parkinson’s models
A Nature Neuroscience study in mouse and cell models reports that losing the Parkinson's risk protein NgBR in microglia triggers ...
Chronic Demyelination Traps Microglia in a Lysosomal Cholesterol State
A Nature Neuroscience study in mouse models and human multiple sclerosis tissue identifies a pro-inflammatory microglial state marked by lysosomal ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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