Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: microglia
Inflammatory stimulation reshapes microglial vesicle miRNA cargo and modestly alters recipient cells
An in vitro study found that LPS-stimulated microglia enriched miR-155 and increased miR-34a in donor cells and their extracellular vesicles, ...
Astrocytes may drive chronic traumatic encephalopathy, scoping review finds
A PRISMA-guided scoping review of 40 studies argues that astrocytes act as early, active contributors to chronic traumatic encephalopathy rather ...
Microglial Activity Patterns Track Tau Buildup in Early Alzheimer’s Disease
A longitudinal PET and fMRI study links two distinct microglial activation signatures, structured by functional brain connectivity, to the spatial ...
Gasdermin D and E Play Distinct Roles in Photoreceptor Degeneration
A new review distinguishes a myeloid gasdermin D inflammatory relay from photoreceptor-intrinsic gasdermin E lysis in retinal degeneration and grades ...
Exercise-linked gene Ticam2 emerges as candidate ALS drug target in mice
A new mouse study links exercise-induced gene-expression changes to the microglial gene Ticam2, which shows potential as a therapeutic target ...
Glycolysis enzymes emerge as central players in Alzheimer’s brain energy failure
A new review argues that dysregulated glycolytic and pyruvate-metabolizing enzymes in specific brain cell types form a central axis linking ...
Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Plant Compound Ivangustin Pins Neuroinflammation on Covalent Hit at UBE2L3 Cys86
A new study reports that ivangustin, a sesquiterpene lactone from Inula japonica, suppresses microglial NF-κB signaling by covalently modifying cysteine ...
Aging Rewrites the Immune Landscape of the Cochlear Spiral Ganglion in Mice
A mouse study in GeroScience found that aged animals showed increased densities of immune- and glia-associated marker-positive cells in the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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