Timing Is Everything: Switching an Immune Switch On and Off Repairs Spinal Cord Injury in Mice
A new mouse study shows that activating the cGAS-STING immune pathway early after spinal cord injury and inhibiting it later ...
Tag: microglia
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
Dental Pulp Stem Cell Secretome Shows Promise for Stroke Recovery in Mice
A Chonnam National University study found that the human dental pulp stem cell secretome reduced oxidative stress and neuroinflammation while ...
Coffee Compound Trigonelline Eases Parkinson’s Symptoms in Mice by Calming Brain Inflammation and Reshaping Gut Microbes
A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...
Lab-grown human brain spheroids show myelin can repair itself after injury
Scientists have engineered human stem cell-derived spheroids containing myelinating oligodendrocytes and reactive microglia that model demyelination and successful remyelination, offering ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Head Trauma May Rewire How the Brain Reacts to Later Stress, Study Finds
An international team led by the University of Malaga has shown in animal models that a prior traumatic brain injury ...
Bacterial Toxin Challenge Gets a Timing Makeover in the Hunt for Brain-Saving Plant Compounds
A new review proposes a kinetics- and mechanism-informed framework for using lipopolysaccharide-induced neuroinflammation models to screen phytochemicals with greater rigour ...
Immune Receptor LAIR1 Blocks Cancer Cell Engulfment in Brain Tumours
New research in the British Journal of Cancer shows that the collagen-binding receptor LAIR1 disables the phagocytic machinery of glioma-associated ...
Hidden RNA Switches in the Human Brain Reveal New Genetic Routes to Alzheimer’s and Parkinson’s Disease
A single-cell atlas of alternative polyadenylation across two million human brain cells reveals a hidden genetic regulatory layer that explains ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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