Higher neuroplasticity marker linked to faster cognitive decline in women only
A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive...
![Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer’s drug design](https://scienmag.com/wp-content/uploads/2026/10/stackrss-featured-39980-350x250.png)
Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer’s drug design
A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's...
FcRn Blockade Lowers IgG and Alters Amyloid Pathology in Alzheimer’s Model Mice
Blocking the neonatal Fc receptor with efgartigimod reduced circulating IgG and was associated with lower amyloid burden and markers of...
People with Parkinson’s disease still read emotions from the way others walk
A study of 38 people with Parkinson's disease and 38 matched controls found that emotion recognition and valence ratings from...
tRNA Fragments May Link Chronic Stress to Translation Failure in Alzheimer’s Disease
A new review proposes that tRNA-derived small RNAs link chronic cellular stress to maladaptive translational remodeling in Alzheimer's disease.
SAT1 Overexpression Eases Alpha-Synuclein Toxicity in Fly Model of Parkinson’s Disease
In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response...
Digital Pathology Tool Quantifies Amyloid Vessels and Plaques in CAA
A validated HALO AI digital pathology pipeline automatically distinguishes CAA-positive vessels from β-amyloid plaques and shows that higher CAA scores...
Neuropsychiatric Symptoms in Alzheimer’s Disease Linked to Amyloid and Heat Shock Proteins
A cross-sectional ADNI study of 713 participants links neuropsychiatric symptoms to lower CSF amyloid-β42 and identifies heat shock protein pathways...
From Association to Cause: Review Maps Causal Inference Methods for Alzheimer’s Molecular Data
A new review surveys causal-inference methods applied to Alzheimer's molecular data, finding that many observational associations lack genetic support and...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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