Icariin, the main bioactive component of Herba Epimedii, reversed nucleolar stress markers in Aβ25–35-treated BV2 cells and APP/PS1 mice, according...

A review integrates associative observations in patients with Alzheimer's disease and mild cognitive impairment alongside experimental and animal findings on...

A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive...

A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing...

Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's...

Blocking the neonatal Fc receptor with efgartigimod reduced circulating IgG and was associated with lower amyloid burden and markers of...

A study of 38 people with Parkinson's disease and 38 matched controls found that emotion recognition and valence ratings from...

A new review proposes that tRNA-derived small RNAs link chronic cellular stress to maladaptive translational remodeling in Alzheimer's disease.

In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response...

A validated HALO AI digital pathology pipeline automatically distinguishes CAA-positive vessels from β-amyloid plaques and shows that higher CAA scores...