Chronic D-serine at 200 mg/kg shows kidney toxicity signs in Parkinson’s disease rats
A rat study finds that eight weeks of daily D-serine at 200 mg/kg produces kidney inflammatory infiltrates and biological alterations,...
Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative...
Low Back Pain Affects Up to 88% of People with Parkinson’s Disease, Review Finds
A scoping review of twelve studies finds low back pain affects an estimated 40% to 88% of people with Parkinson's...
Repurposed Drugs and Herbal Compounds Show Early Promise Against Postmenopausal Alzheimer’s in Rat Studies
A systematic review of seventeen rat studies found that repurposed drugs and herbal compounds improved cognition in a postmenopausal Alzheimer's...
Two SOD1 Aggregate Strains Differ in How Fast ALS-Like Disease Spreads to the CNS
In SOD1G85R mice, sciatic nerve inoculation with two distinct SOD1 aggregate strains transmitted templated aggregation to the CNS, with strain...
Circular RNA circSMOX Emerges as a Player in Muscle and Nerve Disease
A new mini review in Amino Acids summarizes what is known about the circular RNA circSMOX, which is upregulated in...
MRI reveals nigrosome-1 neuromelanin and iron changes in Parkinson disease
Multimodal MRI shows that nigrosome-1 neuromelanin loss and iron changes, with inverted neuromelanin-iron coupling, best mark Parkinson's disease nigral degeneration.
Behavioral Changes May Emerge Years Before Cognitive Decline
A study of 11,781 older adults finds that neuropsychiatric symptom trajectories diverge up to 12 years before MCI and 5...
Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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