Experimental Drug DNL343 Fails to Slow ALS Progression in Randomized Trial
A randomized clinical trial in JAMA Network Open found that 200 mg per day of DNL343, an eIF2B activator, did...
Tau Filaments Act Like Prions, Imposing Their Disease Signature on Mouse Brains
Injecting tau filaments from Alzheimer's and corticobasal degeneration patients into wild-type mice induces endogenous tau pathologies with identical folded structures,...
Parkinson’s Protein Alpha-Synuclein Drives Clogged Arteries by Jamming Cellular Recycling
New research shows that alpha-synuclein, best known for its role in Parkinson's disease, enters macrophages through the protein FLOT1, blocks...
Rapid Syllable Tests at Home Reveal Hidden Motor Signs of Alzheimer’s Risk
A community study of 339 cognitively unimpaired older adults found that motor speech features from self-administered rapid syllable repetition tasks...
Blood Test Clues: Mitochondrial DNA Distinguishes Parkinson’s From Look-Alike Disorder
A new study finds that whole-blood mitochondrial DNA copy number, but not telomere length, clearly distinguishes Parkinson's disease from multiple...
Immune Fingerprints in Blood Reveal Parkinson’s Disease When Patients Are Sorted First
By stratifying Parkinson's patients into mouse-model-anchored immune subtypes, researchers have built T-cell receptor blood tests that exceed 0.8 AUC, overturning...
Blood Test Combo Flags Who Will Develop Parkinson’s Disease Years Early
A new PPMI analysis shows that combining a blood-based microRNA-7-5p measurement with the alpha-synuclein seed amplification assay can identify prodromal...
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson...
New Algorithm Turns a Classic Math Trick Into a Window on How Disease Rewrites the Way We Walk
A French research team has developed DiaSeg, a framework that extracts diagonal segments from Dynamic Time Warping paths to create...
Immune Receptor FcγRIIb Emerges as Gatekeeper of Parkinson’s Protein Spread
New research shows that deleting or blocking the immune receptor FcγRIIb dramatically impairs the spread of alpha-synuclein pathology in the...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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