A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.

A head-to-head laboratory comparison found that SNIPR and synNotch receptors, but not TRUCKs, supported amyloid beta-dependent expression of therapeutic transgenes...

A retrospective feasibility study reports that a deep learning network substantially improved simulated ultra-low-dose multi-tracer PET/MR images in Alzheimer's disease,...

A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and...

A prospective observational study found that plasma pTau181 measured with the Elecsys Phospho-Tau (181P) immunoassay remained stable across varied sample...

A new perspective article argues that osteoporosis prevention deserves far more attention in people with Parkinson's disease, especially when dementia...

A federated learning framework combining MRI and clinical data classifies Alzheimer's disease with reported accuracy up to 94.1 percent while...

A mouse study finds that a triple transgenic Alzheimer's disease model develops measurable skeletal muscle mass, function and innervation deficits...

Researchers in India synthesized five new piperidin-1-yl-phenyl-acetamide derivatives and found that the 2,5-dimethyl compound AS-5 showed the strongest acetylcholinesterase inhibition,...

A laboratory-synthesised rare flavonoid, dichamanetin, protected retinoic acid-differentiated human neuroblastoma cells from hydrogen peroxide-induced damage in vitro, with the strongest...