New Radiotracer Targets Brain Immune Cells With Unmatched Selectivity
Researchers validated 5-MOP, a tritium-labeled radioligand that binds CSF1R with 9.8 nM affinity and far greater kinase selectivity than the ...
Tag: microglia
Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
Thalamus Remodeling May Drive Neuropathic Pain After Spinal Cord Injury
A new review proposes that sustained thalamic remodeling, involving neuroimmune signaling, synaptic changes, and circuit reorganization, may help explain refractory ...
Gut Microbes, Immune Signals and the Inflammatory Road to Parkinson’s Disease
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...
Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
GPNMB–SMAD4 pathway links microglial inflammation to demyelination in diabetic cognitive dysfunction
A mouse and cell study finds that hyperglycemia lowers microglial GPNMB, disrupting its binding to SMAD4 and unleashing NF-κB-driven neuroinflammation ...
First Immune-Modulating Drug Trial Targets Neuroinflammation in Prodromal Parkinson’s Disease
A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...
Mitochondrial Cleanup and a DNA Sensor May Team Up to Drive Stroke Inflammation
A new review maps how mitophagy and the cGAS–STING pathway may jointly regulate post-stroke neuroinflammation through leaking mitochondrial DNA, based ...
Glial cells over-prune synapses in Fragile X syndrome model mice
A study of Fragile X syndrome model mice finds that microglia and astroglia over-engulf synaptic material and that glial signaling ...
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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