Computational screen identifies naringenin as a CXCR4-binding candidate
A multi-method computational screen identified naringenin as the strongest candidate for binding the human CXCR4 receptor, although laboratory and animal ...
Tag: computational biology
TranscriptFormer Maps 112 Million Cells Across 12 Species
TranscriptFormer maps gene-expression profiles from 112 million cells across 12 species, enabling cross-species comparisons, cell-type identification in an unseen species ...
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Graph-learning model reports high drug-response accuracy in cancer cell lines
HGACL-DRP achieved reported mean AUC values of 95.48% and 98.99% on two public cancer cell-line datasets in a computational drug-response ...
PROBE benchmark exposes gaps in AI protein-function annotation
A 1,000-protein, five-organism benchmark found that leading open-source language models showed biological semantic alignment but achieved a best macro-F1 of ...
AI Model SPACER Decodes the Hidden Rules of Cell Recruitment in Human Tissue
An interpretable deep learning model called SPACER reads spatial transcriptomics data to reveal the molecular and spatial rules that govern ...
When Do Gene Network Maps Hold Up? New Study Maps the Robustness Rules of Omics Inference
A systematic reusability study of the CORNETO framework reveals that multi-sample biological network inference operates in distinct robustness regimes governed ...
New Benchmark REACH Exposes How Rare Cancer Cell Detection Methods Collapse Under Pressure
A new reproducible benchmark called REACH evaluates ten computational methods for detecting rare malignant cells in single-cell RNA sequencing data, ...
New Audit Tool Exposes Silent Failures in Microbiome Pipelines
A new open-source tool called ampliconaudit detects silent failures in amplicon taxonomic pipelines by auditing post-hoc artifacts, ensuring that computational ...
New Framework Decodes Plant Transcript Ambiguity
A new multi-evidence framework resolves coding-noncoding ambiguity in the Arrhenatherum elatius transcriptome, identifying 31.71% of transcripts as part of a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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