AI Tool Designs DNA Sequences to Fold Genomes in Desired 3D Patterns
A new computational framework, Akita Semifreddo, combines a fast genome folding model with sequence optimization to design DNA with specified ...
Tag: computational biology
Single-cell tumour phylogenetics
A Nature Reviews Cancer review surveys the statistical and computational methods that reconstruct tumour evolutionary histories from single-cell sequencing data ...
ReadsRatio method traces tissue origins of cell-free DNA across sequencing platforms
A new method called ReadsRatio estimates tissue contributions to circulating cell-free DNA from unmethylated read ratios in cell type-specific marker ...
Ten Rules for Keeping AI Honest in Computational Biology
A new PLOS Computational Biology perspective sets out ten practical rules defining where AI assistance in computational biology is legitimate ...
New metric speeds RNA alignment across arbitrary pseudoknots
SERNA and SERNAlign compare RNA secondary structures with arbitrary pseudoknots using integer sequences, achieving competitive clustering performance at lower computational ...
Computational screen identifies naringenin as a CXCR4-binding candidate
A multi-method computational screen identified naringenin as the strongest candidate for binding the human CXCR4 receptor, although laboratory and animal ...
TranscriptFormer Maps 112 Million Cells Across 12 Species
TranscriptFormer maps gene-expression profiles from 112 million cells across 12 species, enabling cross-species comparisons, cell-type identification in an unseen species ...
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Graph-learning model reports high drug-response accuracy in cancer cell lines
HGACL-DRP achieved reported mean AUC values of 95.48% and 98.99% on two public cancer cell-line datasets in a computational drug-response ...
PROBE benchmark exposes gaps in AI protein-function annotation
A 1,000-protein, five-organism benchmark found that leading open-source language models showed biological semantic alignment but achieved a best macro-F1 of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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