New scCIF framework fuses single-cell multi-omics data for sharper cell clustering
A new open-access framework called scCIF adaptively fuses single-cell multi-omics data and outperformed competing methods on eight public datasets.
Tag: bioinformatics
Six-gene T cell signature predicts survival in hepatocellular carcinoma
A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.
New k-mer estimators untangle substitutions, insertions and deletions in evolving genomes
Researchers have derived closed-form, alignment-free estimators that jointly quantify substitution, deletion and insertion rates from k-mer statistics, with concentration guarantees ...
Genome Mining of 174 Pseudomonas fluorescens Strains Reveals Thousands of Hidden Biosynthetic Gene Clusters
A large-scale bioinformatic survey of the soil and plant-associated bacterium Pseudomonas fluorescens has catalogued thousands of biosynthetic gene clusters scattered ...
Computational Study Points to CYP1B1 as Kaempferol Target in Renal Fibrosis
A computational study combining transcriptomics, machine learning and single-cell analysis identifies CYP1B1 as a potential functional target of kaempferol in ...
New ESMF Method Sharpens Cell-Type Estimates from Bulk RNA Sequencing Data
A new deconvolution framework called ESMF uses single-cell reference data, negative binomial noise modeling and dual-validated marker selection to estimate ...
Deep learning model predicts rice protein interactions from sequence data
A new deep learning framework called RCNNricePPI predicts rice protein-protein interactions from amino acid sequences, achieving an accuracy of 0.8996 ...
Single-cell map reveals how EV-derived miRNAs shape the liver cancer microenvironment
A computational analysis of single-cell RNA sequencing data maps 208 prognosis-linked miRNA-target pairs carried by extracellular vesicles in the hepatocellular ...
New Graph Pangenome Pipeline Simplifies Plant Organelle Genome Analysis
A new pipeline called MineGraph streamlines graph pangenome analysis of plant plastid and mitochondrial genomes, with an application to 709 ...
New Node Embeddings Bring Multiscale EDN Into De Bruijn Graph Learning
Researchers have introduced cMSEDN, a deterministic method that turns multiscale EDN sequence representations into sequence-specific node embeddings for De Bruijn ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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