Study reveals HHV-8-driven immune regulation in HIV-associated and classic Kaposi sarcoma
Kaposi sarcoma is not simply a tumour made of abnormal blood vessels. It is a complex tissue ecosystem in which ...
Tag: tumor microenvironment
Pan-cancer pro-angiogenic atlas reveals tumor-educated pericyte-driven anti-angiogenic resistance
Anti-angiogenic drugs were expected to starve tumors by cutting off their blood supply. Yet many cancers eventually adapt, finding alternative ...
Resting mast cell signature linked to improved outcomes in HR+HER2- breast cancer
Breast cancer remains the most frequently diagnosed malignancy among women worldwide and is responsible for more than 650,000 deaths each ...
Macrophage niches drive dormancy, EMT and chemoresistance in NSCLC stem cells
For years, cancer research has treated tumor cells as relatively stable enemies: cells that multiply, spread and acquire resistance through ...
Scientists locate dormant cancer cells, revealing new treatment targets
Breast tumours may contain hidden “hibernation zones” where cancer cells stop dividing, evade chemotherapy and wait for an opportunity to ...
Spatial Transcriptomics Reveals Histology-Linked Growth Patterns in Colorectal Liver Metastases
A new study is turning the microscopic “how it grows” question in colorectal cancer liver metastases into a measurable molecular ...
Tertiary lymphoid structures contain stem-like tumor-specific T cells
Tertiary lymphoid structures (TLSs)—immune-cell aggregates that form in many solid tumours—have been linked to better outcomes from immune checkpoint blockade. ...
Local Complement C3 Shapes Control Myeloid Infiltration and Checkpoint Blockade Efficacy
A team investigating how tumors respond to immunotherapy reports that complement component C3 plays a decisive role—but only when it ...
Oncogene Inactivation–Triggered Senescence Enables Tumor Relapse
A new study in Nature Communications reveals how cancer cells can use the body’s own defenses against them. The work, ...
Single-Cell Multi-Omics Reveals Cancer-Associated Fibroblast Programs in Breast Cancer
A groundbreaking study has unveiled new insights into the complex biology of cancer-associated fibroblasts (CAFs) within triple-negative breast cancer (TNBC), ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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