Scientists Uncover Why Esophageal Cancer Shrugs Off PD-1 Blockade
A new study shows that the protein SIRPĪ±, produced by esophageal cancer cells themselves, fuels both tumor growth and T-cell ...
Tag: tumor microenvironment
Liver Metastases Shorten Survival on Chemotherapy but Not Immunotherapy in Pancreatic Cancer
A pooled analysis of four clinical trials finds that liver metastases are a strong negative prognostic factor for chemotherapy-treated pancreatic ...
PET Scans and Tumor Immunity: New Study Probes the Hidden Link in Breast Cancer
An exploratory study of 61 breast cancer patients found only weak, statistically fragile links between regional tumor immune-stromal composition and ...
Diabetes Drug Candidate AdipoRon Emerges as Unexpected Driver of Leukemia Blood Vessel Growth
A new correspondence in Molecular Biology Reports highlights evidence that the adiponectin receptor agonist AdipoRon promotes angiogenesis in B-cell leukemia ...
Mini-GRID Radiotherapy Curbs Cellular Senescence While Keeping Its Anti-Tumor Punch in Glioma Cells
A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...
Kidney Cancer Gene Marker CTDNEP1 Signals Survival Differently Across Tumor Subtypes
Researchers in Japan found that high expression of the CTDNEP1 gene predicts poorer survival in clear cell renal cell carcinoma ...
Serotonin Receptor Found to Drive Bone Cancer Spread and Chemotherapy Failure
Researchers report that the serotonin receptor HTR1D drives osteosarcoma metastasis and doxorubicin resistance through a c-MYC/MAPK feedback loop and CCL2/5-HT-mediated ...
Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment
A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...
Massive Multi-Omics Atlas MOSAIC Maps the Hidden Diversity Inside Tumors
The MOSAIC consortium has profiled more than 2,700 tumor samples with spatial and single-cell multi-omics to build a standardized public ...
Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors
A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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