Magnesium Sulfate Shows Neuroprotective Effects in Mouse Model of Postoperative Cognitive Dysfunction
A new experimental study links magnesium sulfate's neuroprotective effects to AMPK/PINK1/Parkin signaling in postoperative cognitive dysfunction.
Tag: PINK1
Salidroside Protects Bovine Mammary Cells From Inflammation by Activating Mitophagy
A new cell-culture study reports that salidroside protects bovine mammary epithelial cells from LPS-induced inflammatory injury by activating AMPK/mTOR signaling ...
Traditional Chinese formula blocks liver cancer cell survival by disabling mitochondrial recycling
A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
Hypomagnetic Fields Extend Lifespan but Impair Mobility in Parkinson’s Fruit Fly Model
Hypomagnetic fields, defined as magnetic environments far weaker than Earth's natural field, produced a sharply split outcome in a laboratory ...
Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts
A new study links lactate-driven protein lactylation to impaired mitochondrial cleanup and activated TGF-β1 signaling, offering a dual mechanism for ...
Earth’s magnetic field may shape ageing, mitochondria and lifespan
University of Nottingham researchers found that shielding fruit flies from Earth's magnetic field altered mitochondrial function, lifespan and physical performance, ...
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Stress-Tagged Ubiquitin Emerges as a Molecular Beacon for Toxic Tau in Alzheimer’s Disease
Mayo Clinic researchers report that ubiquitin phosphorylated at serine 65 is covalently attached to a soluble, oligomeric tau population in ...
Single-Cell Sequencing Reveals Mitochondrial DNA Damage in Vulnerable Parkinson’s Neurons
For the first time, researchers have sequenced mitochondrial DNA from individual vulnerable brainstem neurons in Parkinson's disease, revealing extensive deletions ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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