Intraosseous Cefuroxime Outperforms IV Dosing in Robotic Knee Surgery Trial
A randomized trial found that injecting cefuroxime into bone before robotic-assisted knee replacement achieved far higher tissue concentrations than intravenous ...
Tag: Pharmacokinetics
Antidepressant Discontinuation Research Shifts From Case Reports to Tapering Strategies
A new bibliometric analysis of 1,313 documents shows research on paroxetine and venlafaxine discontinuation has shifted from symptom case reports ...
Warfarin Exposure, Not Standard Monitoring, Tracks Brain Small Vessel Damage in Elderly Stroke Patients
A retrospective cohort study of 300 elderly stroke patients with atrial fibrillation found that model-estimated warfarin exposure, rather than conventional ...
Danshen Compounds Show Promise Against Liver Fibrosis, but Key Evidence Gaps Remain
A critical review finds that Salvia miltiorrhiza compounds can protect hepatocytes and suppress fibrogenic stellate cells, but no single intervention ...
Research report: In vivo blood and ex vivo brain solid-phase microextraction coupled with LC-MS/MS for mapping unbound cannabidiol, phase I metabolites, and endocannabinoid tone
A solid-phase microextraction and LC-MS/MS platform has, for the first time, tracked unbound cannabidiol in the living bloodstream and mapped ...
High Altitude Reshapes Diabetes Drug Dapagliflozin in Rats, With Effects Fading Over Time
A controlled rat study found that simulated 6,000-meter hypoxia raised dapagliflozin exposure 6.58-fold after acute exposure and 2.11-fold after chronic ...
Honey Wound Dressings Offer Coherent Antimicrobial Strategy
Researchers propose a framework of translational plausibility to argue that honey's clinical value lies in topical wound treatments rather than ...
Computational drug screening struggles against drug-resistant tuberculosis, review finds
A new review argues that virtual screening and AI-driven modeling have expanded the search for anti-tuberculosis drugs, but persistent mismatches ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Rifamycins can sharply reduce voriconazole exposure, review finds
A structured review found strong clinical evidence that rifamycins can markedly reduce voriconazole exposure, while evidence for most other antituberculosis ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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