Phase 2b trial of neflamapimod in dementia with Lewy bodies fails to replicate earlier promise
A phase 2b randomized trial found no benefit of neflamapimod on the primary CDR-SB outcome in dementia with Lewy bodies, ...
Tag: Pharmacokinetics
Sildenafil in Newborn Lung Crisis: Review Maps Dosing and Monitoring by Indication
A narrative review consolidates neonatal-specific evidence on sildenafil dosing, monitoring and safety across the main forms of newborn pulmonary hypertension.
Machine learning predicts human oral drug bioavailability from animal data
A machine learning pipeline trained on 192 FDA-approved compounds predicts human oral bioavailability with an R2 of 0.766, outperforming previous ...
Mangrove extract delivers triterpenes fast in rat pharmacokinetic first
A validated HPLC method has captured the first simultaneous pharmacokinetic profiles of betulinic and ursolic acids absorbed from grey mangrove ...
Fixed-Dose Nivolumab Costs More Than Simulated Weight-Based Dosing in Japan
A study of 3,243 Japanese patients found that observed fixed-dose nivolumab billing was a median of 89,540 yen higher per ...
Engineered albumin fusion extends erythropoietin half-life and enables nasal delivery in mice
A human erythropoietin fused to an engineered albumin variant showed a 5.2-fold longer plasma half-life and successful intranasal delivery in ...
Trientine Capsule Comparison Reveals Faster Absorption and Higher Dose-Normalized Exposure in Healthy Volunteers
A randomized crossover study in 35 healthy volunteers found that a 250 mg test capsule and a 300 mg reference ...
First-in-human trial of TEAD inhibitor BPI-460372 shows early signals and safety limits
A first-in-human phase Ia trial reports that the covalent TEAD palmitoylation inhibitor BPI-460372 showed preliminary antitumor activity in advanced solid ...
Transdermal Estradiol Gel Shows Dose-Proportional Blood Levels in Postmenopausal Women
A 14-day pharmacokinetic study in ten Japanese postmenopausal women found that a standardized-area transdermal estradiol gel produced dose-proportional serum estradiol ...
Seizure Drug Levels Plunge in Pregnancy, Chinese Study Warns
A study of 36 Han Chinese women with epilepsy found that levetiracetam and lamotrigine clearance rose sharply during pregnancy, driving ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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