First-in-Human Trial Shows PEGylated Uricase HZBio1 Is Well Tolerated and Slashes Uric Acid
A first-in-human phase 1a trial in China found that single intramuscular doses of the PEGylated recombinant uricase HZBio1 were well ...
Tag: Pharmacokinetics
Blood Pressure Drug Boosts Cancer Medication Levels in Rat Study, Raising Interaction Concerns
A rat study found that the anticancer drug anlotinib substantially increases blood levels of the antihypertensive amlodipine, raising safety concerns ...
Single-Dose Oral NEPA Shows Promise Against Chemotherapy Nausea in Children
A phase 2 dose-finding trial found that a single oral dose of the netupitant-palonosetron combination NEPA effectively prevented chemotherapy-induced nausea ...
Herbal Remedies Quietly Reshape Blood Thinner Levels in Healthy Volunteers
A clinical trial finds that the traditional Korean formulations Bojungikgitang and Cheongsanggyeontongtang substantially raise or lower edoxaban exposure in healthy ...
Generic Diabetes Drug Teneligliptin Proves Bioequivalent in Chinese Volunteers
A randomized crossover trial in 52 healthy Chinese adults found that a generic teneligliptin hydrobromide tablet met all regulatory bioequivalence ...
Melatonin’s Many Promises Face a Pharmacokinetic Reality Check
A new review argues that melatonin's non-sleep therapeutic claims must be re-evaluated through measured drug exposure, since oral bioavailability is ...
Drug Interactions and Side Effects Shape Safe Prescribing of Lung Cancer Pills
A comprehensive review maps how food, acid-reducing drugs and liver enzymes alter the exposure of thirty lung cancer targeted therapies, ...
Subcutaneous Tarlatamab Shows Safety and Early Activity in Small Cell Lung Cancer
A phase 1b study presented at the IASLC 2026 World Conference on Lung Cancer found that subcutaneous tarlatamab was well ...
New Study Tracks How Bilirubin Moves Through Preterm Infant Bodies
A 2026 Journal of Perinatology study examines how bilirubin production, distribution, and clearance differ in preterm infants, informing safer jaundice ...
Black Pepper Compound Piperine Emerges as Powerful Potential Parkinson’s Drug in Landmark Study
A new computational study shows that piperine, the pungent alkaloid of black pepper, binds the Parkinson's-related MAO-B enzyme more strongly ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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