Simulated Patients Replace Human Trials in Virtual Test of Roxithromycin Drug Equivalence
Chinese researchers validated a physiologically based pharmacokinetic model of roxithromycin and used it to run a virtual bioequivalence trial in ...
Tag: Pharmacokinetics
Human Organs on Chips Recreate Body’s Niches to Predict Drug Safety
A Stanford-led review in Nature Biomedical Engineering maps how multi-organ tissue chips that preserve each organ's native niche could transform ...
Nanocarrier With Built-In Efflux Blocker Lifts Luteolin Absorption 29-Fold
Researchers engineered a TPGS-based self-microemulsifying delivery system that boosts luteolin's oral bioavailability 29-fold by simultaneously improving solubility, uptake and P-glycoprotein ...
Beyond Killing Germs: Phages and Microbial Functions Drive Next-Generation Medicine
A new review proposes post-microbial therapeutics, a framework that uses bacteriophages and validated microbial modules to link microbial perturbation to ...
Blood Pressure Drug Valsartan Found at Double Normal Levels in Driver Who Crashed
Forensic scientists in Hannover report a road traffic case in which the blood pressure drug valsartan reached 12.7 micrograms per ...
Prefilled Syringe Delivers Autoimmune Drug Efgartigimod as Fast and Effectively as the Vial
New studies show a prefilled syringe of efgartigimod PH20 is bioequivalent to the vial presentation, safe to inject in as ...
Doxorubicin Doses Hit the Same Dogs Differently, Landmark Canine Study Reveals
A prospective study of seven dogs with cancer shows that doxorubicin exposure varies far more between patients than within them, ...
Death by Blood Pressure Pill? Forensic Study Maps When Amlodipine Turns Lethal
A retrospective French autopsy study of 33 cases establishes postmortem amlodipine concentration thresholds and shows that redistribution after death can ...
Sildenafil for Newborn Lung Disease: What the Evidence Really Shows
A new review argues that sildenafil's short-term benefits in bronchopulmonary dysplasia-associated pulmonary hypertension mask unresolved questions about long-term vascular remodeling, ...
Biosimilar Trastuzumab EG12014 Matches Original Drug in Phase III Breast Cancer Trial
A Phase III trial of 807 patients found the trastuzumab biosimilar EG12014 statistically equivalent to reference trastuzumab in efficacy, safety, ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!