Oral Ketamine Lozenges Prove Impractical for Chronic Pain in Dogs with Osteoarthritis
A small clinical trial found an oral transmucosal ketamine lozenge was successfully administered in only 54 percent of doses in ...
Tag: Pharmacokinetics
When Immune Defenses Fail, Antibiotics Fight Alone Against Resistant Bacteria
A new review explains how neutrophil, complement, and barrier defects reshape antibiotic activity in immunocompromised patients with resistant bacterial infections.
Research report: Obesity and Early Biologic Failure in Psoriasis: An Italian Multicentre Retrospective Cohort Study
A retrospective Italian cohort study of 573 psoriasis patients found that obesity was associated with a nearly threefold higher risk ...
Crossing the Blood-Brain Barrier Is Only the First Step for CNS Drugs
A new review argues that crossing the blood-brain barrier is only the starting point of CNS drug delivery, with perivascular ...
Follow-Up Vancomycin Drug Monitoring Linked to Lower Kidney Injury Risk in Japanese Claims Study
A retrospective Japanese claims database study of 492 adults found follow-up vancomycin therapeutic drug monitoring within one week was associated ...
Nano Cubosome Gel Boosts Flibanserin Skin Delivery Nearly Twofold in Rats
Scientists optimized a flibanserin-loaded cubosomal hydrogel that roughly doubled systemic drug exposure compared with an oral suspension in a rat ...
Scoping Review Finds Only Lab Evidence Behind High-Dose Naloxone and Nalmefene
A scoping review of ten studies finds that evidence on high-dose naloxone and nalmefene comes almost entirely from pharmacokinetic research ...
Plasma Levels of Methylphenidate Track Clinical Response in Youth with ADHD Better Than Urine Tests
A study of 311 youth with ADHD found that plasma concentrations of methylphenidate showed stronger links to symptom response and ...
Milk thistle extract shows antifibrotic promise but fails clinical translation
A new critical review finds that silymarin shows broad preclinical antifibrotic activity across multiple organs, but heterogeneous formulations, low oral ...
Once-Daily Gabapentin Gastroretentive Tablet Matches Gralise in Fed Bioequivalence Trial
A randomized crossover trial in 24 healthy men found Sun Pharma's once-daily gastroretentive gabapentin 600 mg tablet was bioequivalent to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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