LC–MS/MS emerges as the workhorse of modern drug development
A new review maps how liquid chromatography–tandem mass spectrometry now quantifies drugs, metabolites, genotoxic impurities and proteins across every stage ...
Tag: Pharmacokinetics
Naloxone’s molecular blueprint holds the key to next-generation opioid overdose antidotes
A comprehensive review of naloxone's chemistry, receptor pharmacology and clinical pharmacokinetics explains why the lifesaving opioid antagonist acts so quickly ...
Drug Residues Linger in Cooked Meat and Milk, Review Warns
A new review argues that veterinary drug residues persist through cooking and fermentation, while emerging detection technologies remain too immature ...
Nasal Spray Harm Reduction Framework Proposed for Snorting Cocaine, MDMA and Ketamine
A harm reduction journal article outlines a practical framework for dissolving psychoactive powders in sterile saline and delivering them with ...
Fc-Free CLDN18.2 × CD3 Antibody AHT-102 Shrinks Gastric Tumors in Mice
A new Fc-free CLDN18.2 × CD3 bispecific antibody called AHT-102 showed dose-dependent tumor suppression, tumor-selective tissue distribution, and no systemic ...
Long-Acting GLP-1/GIP Dual Agonist Shows Weekly Dosing Potential in Healthy Cats
A pharmacokinetic study in 48 healthy cats found the GLP-1/GIP dual agonist HDM7006 has a roughly 44-hour half-life, dose-proportional exposure ...
Single IV Aprepitant Dose Cut Postoperative Vomiting Risk in Chinese Trial
A multicenter randomized trial in China found that a single 32 mg intravenous dose of aprepitant given before anesthesia induction ...
Generic Piracetam Tablet Proves Bioequivalent to Nootropyl in Healthy Chinese Volunteers
A randomized crossover trial in 56 healthy Chinese participants found a generic 800-mg piracetam tablet bioequivalent to the reference product ...
Low-Dose Iohexol Infusion Tracks Kidney Filtration in Pigs
A tailored continuous low-dose iohexol infusion protocol reached a stable plateau within 120 minutes in anesthetized pigs and measured glomerular ...
Research report: The Influence of Renal or Hepatic Impairment on the Pharmacokinetics of Iclepertin (BI 425809): Results from Two Phase I Open-Label, Non-randomised, Single Dose, Parallel Design Studies
Two Phase I studies found that a single 10 mg dose of iclepertin raised drug exposure in severe renal and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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