High Altitude Reshapes Diabetes Drug Dapagliflozin in Rats, With Effects Fading Over Time
A controlled rat study found that simulated 6,000-meter hypoxia raised dapagliflozin exposure 6.58-fold after acute exposure and 2.11-fold after chronic ...
Tag: Pharmacokinetics
Honey Wound Dressings Offer Coherent Antimicrobial Strategy
Researchers propose a framework of translational plausibility to argue that honey's clinical value lies in topical wound treatments rather than ...
Computational drug screening struggles against drug-resistant tuberculosis, review finds
A new review argues that virtual screening and AI-driven modeling have expanded the search for anti-tuberculosis drugs, but persistent mismatches ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Rifamycins can sharply reduce voriconazole exposure, review finds
A structured review found strong clinical evidence that rifamycins can markedly reduce voriconazole exposure, while evidence for most other antituberculosis ...
Ferroptosis framework maps how iron-driven cell death could be pushed or blocked for precision drugs
A new Perspective proposes a unified pharmacological-toxicological framework treating ferroptosis, mitochondrial stress and redox imbalance as one axis governing both ...
Antiviral Drug Behavior Varies Widely Across Rare Bird Species
A pharmacokinetic study of baloxavir marboxil in 14 avian species reveals marked interspecies differences in drug exposure, informing species-specific dosing ...
Severe obesity complicates ICU drug dosing, review concludes
A narrative review concludes that severe obesity can complicate ICU drug dosing and supports individualized regimens based on pharmacokinetic variability ...
Mapping the subcellular pharmacokinetic-pharmacodynamic landscape: a systems-pharmacology framework for predicting combination therapies against intracellular bacterial infections
A targeted narrative review proposes a systems-pharmacology framework for designing antibiotic combinations around drug exposure, bacterial state and location within ...
Paediatric esketamine evidence points to context-specific doses, not universal safety threshold
A targeted review finds that 0.2–0.5 mg·kg−1 intravenous esketamine is the best-studied range for selected paediatric emergence-prevention settings, but not ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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