Blocking Autophagy in Lung Macrophages Boosts Immune Priming Against Infections
Autophagy in alveolar macrophages restrains IL-1α production, and blocking it primes innate immunity that speeds clearance of bacterial and viral ...
Tag: mouse models
Gum bacterium’s serpin disarms rival pathogen’s key virulence protease
A serpin called miropin made by Tannerella forsythia inhibits the gingipain K protease of Porphyromonas gingivalis, reducing its growth and ...
Compact engineered Cas12m enables multiplexed CRISPR gene activation in mice
An engineered compact Cas12m variant enables multiplexed CRISPR gene activation from a single AAV vector in mouse models.
Leukemia cells lacking PTEN reveal a metabolic weakness that approved drugs can exploit
Loss of PTEN makes T-cell acute lymphoblastic leukemia cells dependent on the guanylate-synthesis enzyme IMPDH, allowing clinically approved IMPDH inhibitors ...
Immune cells in the gut act as an unexpected shield against inflammation
A mouse study finds that IL-2-producing TFH cells sustain regulatory T cells in gut-associated lymphoid tissues, and their loss triggers ...
Endothelial TXNIP emerges as a driver of pulmonary vascular remodeling
A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...
Sox3 Keeps the Actin Core of Hair Cell Stereocilia Stable for Lifelong Hearing
A mouse study finds that the transcription factor Sox3 preserves the actin core of hair cell stereocilia, and that its ...
CD4 T Cell Help Powers Immunotherapy Response in Tumors Lacking MHC-I
Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...
Astrocyte Subtype Marked by CD51 Drives Synapse Formation and Stroke Recovery in Mice
A new mouse tool reveals that CD51-positive astrocytes are a functionally distinct subpopulation that promotes cortical synapse formation, hippocampal circuit ...
Progranulin Loss Impairs Cathepsin D Activity and Raises Insoluble TDP-43 in Mouse Brains
A mouse study finds that progranulin deficiency impairs cathepsin D enzymatic activity despite elevated protein levels, disrupts lysosomal organization, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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