Leaking Mitochondrial DNA Emerges as a Central Engine of Cellular Aging
A new review in Biogerontology argues that leaking mitochondrial DNA activates the cGAS-STING innate immune pathway in senescent cells, sustaining ...
Tag: mitophagy
Transplanted Mitochondria Rejuvenate the Aging Heart by Restarting Cellular Cleanup
Injecting healthy mitochondria from stem cells into aged mice restored cardiac function by reactivating a blocked mitochondrial waste-disposal pathway controlled ...
Gut Metabolites From Pomegranate Rewire Human Muscle Cells in Surprisingly Different Ways
A new transcriptomic study shows that the gut microbial metabolites urolithin A and urolithin B, derived from pomegranate polyphenols, rewire ...
How Autophagy’s Dual Role Shapes Inflammatory Bowel Disease
A sweeping new review maps how canonical, selective, and non-autophagic functions of autophagy genes jointly determine the course of inflammatory ...
Ancient Chinese Herbal Formulas Show Promise as Multi-Target Anti-Aging Therapies
A sweeping review maps classical Chinese medicine formulas onto the fourteen hallmarks of aging, revealing multi-target molecular mechanisms and clinical ...
How Failing Cellular Housekeeping Fuels Brain Disease Through a Viral Alarm System
A new review in the Journal of Translational Medicine details how impaired mitophagy allows mitochondrial DNA to trigger cGAS–STING-driven neuroinflammation ...
Ancient Herbal Medicine Emerges as a Multi-Target Weapon Against Alzheimer’s Disease
A new review maps how traditional Chinese medicine compounds simultaneously target seven core Alzheimer's disease mechanisms through a hierarchical network ...
Kisspeptin-10 Shows Promise Against Obesity-Driven Testicular Damage in Rat Study
A new rat study shows the puberty-regulating hormone Kisspeptin-10 reduces testicular oxidative stress, improves sperm quality, and boosts mitophagy-related proteins ...
Fatty Acids Take Command: How a Ribosome Guardian and a Lipid Mediator Shield the Mitochondria
A new GeroScience study reveals that the Mediator subunit MDT-15, box C/D snoRNPs, and fatty acid metabolism jointly regulate mitochondrial ...
A single ubiquitin enzyme emerges as a master switch between liver repair and liver destruction in MASH
Researchers report that loss of the K63-linked ubiquitination enzyme UBE2N in hepatocytes drives metabolic dysfunction-associated steatohepatitis by blocking p62-mediated mitophagy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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