Hidden Protein Brake on Plaques Reveals New Path Beyond Cholesterol
Researchers in Shanghai have discovered that the protein TXNIP suppresses dangerous plaque angiogenesis by degrading the glycolytic enzyme HK2 and ...
Tag: mitophagy
DNA Repair Protein APEX1 Emerges as Key Guardian of Egg Cell Quality
New research shows that the DNA repair and redox-signaling protein APEX1 protects oocyte quality by sustaining mitophagy and suppressing iron-dependent ...
Cellular Recycling Switch SIRT1-FOXO1 May Hold Key to Taming Brain Inflammation
New research shows that the SIRT1-FOXO1 signaling axis acts as a molecular brake on excessive mitophagy and glycolytic metabolism in ...
Mitochondrial DNA Mosaics May Serve as a Molecular Clock of Human Aging
A new review argues that clonally expanded mitochondrial DNA mutations accumulate in a tissue-specific, biphasic pattern that can be read ...
Calcium-Rich Bone Environment Helps Osteosarcoma Cells Survive Chemotherapy
Researchers have discovered that the calcium-rich bone microenvironment drives chemotherapy tolerance in osteosarcoma through an ORAI3–Ca²⁺–NFAT4–PINK1 mitophagy axis that can ...
Chemotherapy’s Hidden Survivors: Lactylation Switch Reveals How Colorectal Cancer Cells Hide From Treatment
A new Molecular Cancer study reveals how UQCRC2 lactylation and SIRT1-driven mitophagy allow colorectal cancer cells to survive chemotherapy in ...
Ubiquitin Enzyme UBE2N Emerges as Master Switch Between Liver Repair and Damage
A new Nature Metabolism study identifies the ubiquitin-conjugating enzyme UBE2N as the molecular switch that determines whether hepatocytes undergo protective ...
Mitophagy-Driven Mitochondrial DNA Release Connects Radiation to Immunogenic Death in Pancreatic Cancer
Pancreatic cancer may be one of the most difficult cancers to treat, but new research points to a microscopic event ...
Mitophagy dampens mitochondrial DNA–triggered cGAS-STING activation in autoimmune thyroiditis
Viral science news: Autoimmune thyroiditis has long puzzled researchers with how mitochondrial material sparks an inflammatory cascade that ultimately damages ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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