How Doxorubicin Hijacks the Heart’s Cellular Cleanup Crew — and Why It Matters
A sweeping review reveals how the chemotherapy drug doxorubicin breaks the heart's mitochondrial and ER recycling systems at multiple checkpoints, ...
Tag: mitophagy
Fibrosis Signal BMP4 Drains Kidney Cells’ Mitochondrial Power in Diabetic Disease
New research shows that the pro-fibrotic signal BMP4 drives mitochondrial dysfunction in kidney mesangial cells by suppressing Parkin, a key ...
From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Reactive oxygen species hold the key to repairing damaged peripheral nerves
A new review reveals how reactive oxygen species both drive and derail Schwann cell–mediated nerve repair, and how smart biomaterials ...
When Mitochondria Fail, Inflammatory Cell Death Follows in Brain and Spinal Cord Injury
A new review links mitochondrial failure to the inflammatory hybrid cell death program PANoptosis across stroke, hemorrhage, traumatic brain injury, ...
Salamander-Inspired Nanocages Deliver Drugs Deep Into Injured Kidney Cells
Researchers have engineered salamander-inspired gold-silver nanocages that cascade-target injured kidney cells and their mitochondria, delivering the antioxidant idebenone while enabling ...
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Damaged Mitochondrial DNA Emerges as a Central Driver of Pulmonary Arterial Hypertension
A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...
Plant Compounds Emerge as Potential Dual Blockers of Brain-Damaging Enzymes
A computational study identifies plant-derived compounds, notably coumarin, as promising dual inhibitors of the ROCK1 and ROCK2 enzymes that regulate ...
Gut Bile Acid Rejuvenates Aging Bone Stem Cells to Fight Postmenopausal Osteoporosis
A gut bacteria-derived bile acid called hyodeoxycholic acid restores aging bone marrow stem cells and reverses bone loss in a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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