Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Tag: mitophagy
How Failing Mitochondria Turn Cells Into Engines of Ageing Inflammation
A new GeroScience review details how failing mitochondria act as both initiators and amplifiers of cellular senescence and the chronic ...
How Pathogens Hijack Mitophagy and What It Means for Treating Infection
A new review details how bacteria and viruses hijack or block the mitochondrial quality-control pathway of mitophagy to survive, evade ...
How Broken Mitochondria Drive the Scarring That Slowly Kills the Kidneys
A sweeping new review argues that damaged mitochondria in kidney tubule cells act as both trigger and amplifier of the ...
Aging Eye Study Uncovers Molecular Cascade Behind Blinding Retinal Scarring
Researchers have identified a LAPTM5-WWP2-OPTN mitophagy cascade that drives retinal pigment epithelium senescence and subretinal fibrosis through cGAS-STING activation, with ...
Calpain Blocker Restores Cellular Cleanup Crew and Protects Blood Vessels in Diabetes
A new study shows that overactivated calpains block autophagy and mitophagy in endothelial cells under high glucose, and that inhibiting ...
Gut Microbes Turn Amino Acid Into Toxin That Worsens Pancreatitis in the Elderly
New research in Microbiome shows that age-related expansion of Escherichia-Shigella bacteria in the gut elevates phenylalanine-derived metabolites that damage pancreatic ...
Ancient Chinese Herbal Formula Shows Promise Against Type 2 Diabetes Through a Cellular Recycling Pathway
A new study combining network pharmacology, genetic causal inference, and mouse experiments shows that the traditional Chinese formula Banxia Xiexin ...
How Tumor Mitochondria Help Cancer Hide From the Immune System
A new review in the Journal of Translational Medicine details how mitochondrial metabolic reprogramming in tumor cells drives immune evasion ...
Leaking Mitochondrial DNA Emerges as a Central Engine of Cellular Aging
A new review in Biogerontology argues that leaking mitochondrial DNA activates the cGAS-STING innate immune pathway in senescent cells, sustaining ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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