Epigenetic Editing Steps Closer to the Clinic as Bioengineering Tools Mature
The EpiBio-24 conference in Amsterdam showcased maturing epigenetic engineering tools, durable gene silencing in animal models, and growing clinical momentum ...
Tag: chromatin
Open Chromatin Is Not So Open: Active Genes Ride on Condensed Domains
New simulations reveal that euchromatin is mostly condensed into dense domains, with short active regulatory regions protruding on their surfaces ...
Gravity leaves the human genome largely unfazed, microgravity simulator reveals
NYU physicists built a custom microgravity simulator and found that the human genome's organization and dynamics remain robust after 24 ...
Epigenetics Moves From Lab Bench to Bedside as Naples Conference Showcases Bold Advances
The 4th Clinical Epigenetics International Conference in Naples highlighted rapid progress in epigenetic mechanisms, editing technologies, and therapies for cancer, ...
Cryo-EM Reveals How Polycomb Repressive Complex 1 Assembles, Works and Finds Its Targets
Ciapponi and colleagues have determined the cryo-EM structure of the canonical PRC1 holocomplex, revealing how its architecture coordinates assembly, H2A ...
Reading the Genome One Molecule at a Time: A Practical Guide to Single-Molecule Genomics
Leading genome researchers have published a practical guide in Nature Reviews Molecular Cell Biology explaining how single-molecule genomics can reveal ...
The Brain May Be Built From Two Separate Embryonic Lineages
A new Nature Neuroscience study shows that the mammalian brain is assembled from two parallel lineage-restricted progenitors that emerge simultaneously ...
Cancer Reshapes the SUMOylation Landscape to Sabotage Muscle Function, Study Finds
New research reveals that cancer reorganizes the SUMOylation landscape in skeletal muscle and alters L3mbtl2-mediated transcriptional control, offering a molecular ...
Cohesin Builds Molecular Fences That Keep Active Genome Domains From Mixing
New research shows that the cohesin complex acts as a molecular barrier in living human cells, preventing condensed euchromatic domains ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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