Researchers have developed KAS-CUT&Tag, an assay combining N3-kethoxal labeling and targeted tagmentation to directly map single-stranded transcription bubbles across the ...
A proteome-wide study reveals that clustered O-GlcNAc modifications in intrinsically disordered regions cooperatively regulate biomolecular condensates and transcriptional programs controlling ...
Chemically synthesized dual-monoubiquitinated PAF15 directly activates the maintenance DNA methyltransferase DNMT1 by relieving autoinhibitory domain interactions, structural and biochemical experiments ...
A review in Cell Communication and Signaling examines PHF20 as a candidate stabilizer of persistent transcriptional states in chronic injury, ...
Researchers discover that the breast cancer drug fulvestrant promotes estrogen receptor DNA binding and active histone acetylation despite leaving chromatin ...
A time-course investigation shows how progressive chromatin remodeling and key regulatory factors direct human embryonic stem cells into kidney organoids.
A comprehensive review published in Epigenetics & Chromatin in March 2026 connects two previously distinct areas of biological research: intrinsic ...
A study in Cell Death Discovery shows that excess cholic acid impairs oocyte maturation by depleting linker histone H1.2, leading ...
Researchers reconstituted complex three-dimensional chromatin folding and topologically associating domains in a cell-free system using Drosophila syncytial embryo extracts.
A comprehensive review of 309 studies reveals that chromatin remodeling complexes drive the progression and phenotypic heterogeneity of major cardiomyopathies, ...
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