ABCA1 cholesterol trafficking implicated in Parkinson’s neurodegeneration in mice
Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.
Tag: autophagy
Autophagy’s Context-Dependent Roles Shape Solid-Tumor Treatment Strategies
A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors ...
Lysosomal pH emerges as a context-dependent amplifier in septic lung injury
A review identifies lysosomal pH dysregulation as a plausible context-dependent amplifier of sepsis-associated lung injury, but finds that most supporting ...
Cellular Recycling Pathway Slows Aging by Keeping Senescent Cells in Check
Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...
Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
Lysosomes Emerge as Central Players in Lung Development and Pediatric Lung Disease
A new review reveals how lysosome–autophagy networks orchestrate lung maturation and may reshape treatment of bronchopulmonary dysplasia, cystic fibrosis, and ...
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Cellular Recycling System Emerges as Master Switch for Healing Chronic Wounds
A new review details how the cellular recycling pathway autophagy coordinates every stage of skin wound healing and how drugs, ...
miR-486: the cardiac microRNA that shields the heart from reperfusion injury
Every year, millions of people survive heart attacks because modern medicine can reopen blocked coronary arteries with remarkable speed. Yet ...
Brief Limb Ischaemia Cycles Shield the Kidneys by Switching On a Mitochondrial Cleanup Pathway
New research shows that remote ischaemic preconditioning protects kidneys from reperfusion injury by activating SIRT3-dependent, Parkin-mediated mitophagy in renal tubular ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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