BAG3-HSP70 Autophagy Axis Emerges as Contested Target in Leukemia
A rigorous new review finds that the BAG3-HSP70 autophagy axis is prognostically relevant and pharmacologically tractable in acute myeloid leukemia, ...
Tag: autophagy
Autophagy-Boosting Peptide Tat-Beclin1 Adds to Endurance Training Gains in Aged Mice
A cell-permeable peptide that activates autophagy improved grip strength, endurance, and balance in aged mice and produced gains comparable to ...
Ginsenoside Rg3 Extends Lifespan in Worms by Rewiring Lysosomal and Autophagy Pathways
A ginseng compound slowed neuronal aging in Caenorhabditis elegans through phosphoinositide signaling, TOR suppression, and HLH-30/TFEB activation, offering a new ...
How Doxorubicin Hijacks the Heart’s Cellular Cleanup Crew — and Why It Matters
A sweeping review reveals how the chemotherapy drug doxorubicin breaks the heart's mitochondrial and ER recycling systems at multiple checkpoints, ...
Ginseng Compounds Show Promise for Blood Disorders but Face Steep Translational Hurdles
A new review finds that ginseng-derived ginsenosides show context-dependent effects on healthy and malignant blood cells in laboratory models, but ...
Q Fever Bacterium Hijacks Host Protein Recycling Machinery to Build Its Replicative Home
Researchers have discovered that the Q fever bacterium Coxiella burnetii uses a secreted effector protein called CelF to competitively block ...
Stomach Surgery Slows Alzheimer’s Disease in Mice, Study Finds
New research in Aging Cell shows that sleeve gastrectomy reduced amyloid plaques, neuroinflammation, and diet-exacerbated memory deficits in Alzheimer's model ...
From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Tiny RNA Molecule Reveals How Nerves Fight Back Against Chemotherapy Damage
Researchers in South Korea have shown that the microRNA miR-378f directly targets CAB39 to regulate AMPK/mTOR signaling and autophagy, revealing ...
Cellular Bubbles and Molecular Trash Tags: A New Route for Antibody Drugs Into the Brain
University of Ottawa researchers report that extracellular vesicles can ferry engineered antibodies across the blood-brain barrier, and that tagging disease ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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