Tag: autophagy

Researchers report that the ALS-linked kinase TBK1 clears aggregation-prone monomeric TDP-43 in neurons by inducing interferon-β and the immunoproteasome, an ...

A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...

A newly designed cell-penetrating peptide that inhibits the autophagy enzyme ATG4 raised reactive oxygen species and significantly reduced tumor size ...

An in vitro study of human esophageal epithelial cell lines found that brief alcohol exposure promoted autophagy-driven growth while longer ...

A new review synthesizes preclinical evidence that the CaMKIIδ kinase integrates calcium dysregulation, inflammation, autophagy failure, mitochondrial decline and DNA ...

A new study identifies Atg5-dependent Treg regulation as a mechanistic link between Treg dysfunction and macrophage inflammation in kidney antibody-mediated ...

In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response ...

A new narrative review synthesizes how the multifunctional protein JWA intersects with redox homeostasis across cancer, neurodegeneration and tissue injury, ...

In a rat model of chemically induced liver cancer, combining oral quercetin with fractionated low-dose gamma irradiation outperformed either treatment ...

A study combining bibliometric mining, network pharmacology and mouse experiments identified the plant flavonoid kaempferol as a candidate compound against ...