Cancer
$2.7 million grant to explore hypoxia’s impact on blood stem cells
INDIANAPOLIS — Indiana University School of Medicine scientists are on a mission to understand why hematopoietic stem cells, responsible for producing all types of mature blood cells, exhibit better responses in a low-oxygen environment within the bone marrow, also known as...
A shortcut for drug discovery
For most human proteins, there are no small molecules known to bind them chemically (so called “ligands”). Ligands frequently represent...
Vitamin D availability enhances antitumor microbes in mice
Dietary vitamin D modulates the gut microbiome to enhance the response to cancer immunotherapies, according to a new study in...
Study uncovers drug target in a protein complex required for activation of NF-κB, a transcription factor involved in multiple diseases
RESEARCH SUMMARY RESEARCH SUMMARY Study Title: Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory...
Circadian rhythms can influence drugs’ effectiveness
CAMBRIDGE, MA -- Giving drugs at different times of day could significantly affect how they are metabolized in the liver,...
Cancer survivors reporting loneliness experience higher mortality risk, new study shows
A new study led by researchers at the American Cancer Society (ACS) showed people surviving cancer who reported feeling more...
Insilico Medicine receives IND approval from FDA for novel MAT2A inhibitor ISM3412
Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine (“Insilico”) announces that it has received approval from the U.S....
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy...
International DNA Day launch for Hong Kong’s Moonshot for Biology
International DNA Day Launch for Hong Kong’s Moonshot for BiologyCredit: Earth Biogenome Project: Hong Kong International DNA Day Launch for...
A closed-loop drug-delivery system could improve chemotherapy
When cancer patients undergo chemotherapy, the dose of most drugs is calculated based on the patient’s body surface area. This...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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