Viral Z-RNA Sensor ZBP1 Emerges as a Switch to Turn Cold Tumors Hot for Immunotherapy
Researchers argue that the innate immune sensor ZBP1, which detects left-handed Z-form nucleic acids and triggers necroptosis, can be pharmacologically ...
Tag: ZBP1
Cigarette Smoke Reprograms Lung Stem Cells, Steering Which Cancer Takes Hold
A Johns Hopkins study shows chronic cigarette smoke exposure reprograms distinct lung stem cell populations through epigenetic changes, determining whether ...
Infection Rewires a Histone Tag to Boost Macrophage Defenses Through an ID3-ZBP1 Circuit
A new study shows that Salmonella infection removes an acetyl tag from histone H2B, silencing the ID3 gene and weakening ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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