CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Tag: tumor microenvironment
Tiny Cell Structures Called Migrasomes May Predict Gastric Cancer Outcomes
A new study links fibroblast-derived migrasome programs and the protein TSPAN4 to gastric cancer progression and builds a highly accurate ...
CYP2S1 enzyme linked to immunotherapy resistance in esophageal cancer
New research identifies the enzyme CYP2S1 as a driver of immunosuppressive cell recruitment and poor chemoimmunotherapy response in esophageal squamous ...
Immune Cells Inside Breast Tumours May Signal Spread to Lymph Nodes
A Malaysian study of 241 early breast cancer patients finds that higher levels of tumour-infiltrating lymphocytes are linked to lower ...
RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
Tumour Matrisome Emerges as a Rich Source of Cancer Biomarkers and Drug Targets
A new review in Nature Reviews Clinical Oncology details how the tumour extracellular matrix, or matrisome, drives cancer progression and ...
PD-1 and LAG-3 Double-Positive T Cells Predict Better Gastric Cancer Survival
A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Scientists Decode Colorectal Tumors With Imaging and Multi-Omics Fusion
A new review in the Journal of Translational Medicine maps how radiomics, pathomics and multi-omics integration can decode the tumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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