Epigenetic Aging Inside Tumors May Shape Immunotherapy Response Beyond Chronological Age
A new review synthesizes evidence that DNA methylation, chromatin and non-coding RNA changes reshape immune and stromal cells in the ...
Tag: tumor microenvironment
Engineered Bacteria Deliver Two-in-One Immunotherapy Directly to the Pleural Cavity in Mice
An engineered non-pathogenic bacterium carrying a PD-L1 blocker and IL-15 significantly suppressed pleural tumors and fluid buildup in a mouse ...
Single-Cell Map of Androgen Receptor States in Resistant Prostate Cancer
An exploratory single-cell RNA sequencing study maps androgen receptor-associated cellular states in castration-resistant prostate cancer while explicitly avoiding AR-V7 classification ...
SERINC2 protein emerges as potential target for preventing brain metastasis
Duke pathology researchers report that the membrane protein SERINC2 remodels phosphatidylserine to activate AXL signaling and reshape the brain immune ...
Aptamers Emerge as Programmable Building Blocks for Precision Cancer Immunotherapy
A new review maps how engineered DNA and RNA aptamers could enable targeted delivery and tumor microenvironment remodeling in precision ...
Natural Killer Cells in Liver Metastasis Prove Far More Than Simple Killers
A new review argues that natural killer cells in colorectal cancer liver metastasis form a heterogeneous, microenvironment-shaped spectrum of states ...
Lactate Signal H3K18 Lactylation Shows Dual Roles in Human Disease
A new review maps how the histone lactylation mark H3K18la links lactate metabolism to gene control, driving both disease progression ...
Engineered Organoid Platforms Bring Causal Rigor to Gut Microbiota-Cancer Research
A new review maps which engineered organoid platforms can turn gut microbiota-cancer associations into causal evidence, and where the current ...
Fibroblasts May Help Endometrial Tumors Evade Immunity, but the Evidence Is Still Patchy
A new review finds that while cancer-associated fibroblasts clearly promote tumor growth and suppress natural killer cell activity in endometrial ...
Macrophages, Fibroblasts and Cancer Cells Conspire to Switch On a Tumor-Fueling Protein in Pancreatic Cancer
A new study shows that cooperative signals from macrophages, stellate cells and cancer cells switch on the tumor-promoting protein CHI3L1 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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