SIRPα promotes triple-negative breast cancer brain metastasis in models
A preclinical study found that SIRPα signaling inside triple-negative breast cancer cells promoted mitochondrial fission, motility, immune tolerance and brain ...
Tag: tumor microenvironment
B7-H3 blockade and MEK inhibition overcome immune defenses in prostate cancer models
In preclinical castration-resistant prostate cancer models, combining B7-H3 blockade with the MEK inhibitor trametinib overcame compensatory immune suppression and structural ...
Antibody–drug conjugates amplify cancer immunotherapy in selected solid tumors
A review of clinical and preclinical evidence finds that antibody–drug conjugates can improve outcomes with immune checkpoint inhibitors in several ...
Polarized-light imaging maps physics-based contrasts in melanoma histology slides
A computational polarimetric imaging framework combining differential Mueller matrix decomposition, wide-field image stitching and pseudo-color visualization revealed depolarization as a ...
Dual Blockade of CD44v6 and PI3K Undermines Colorectal Cancer Stem Cell Reprogramming
A preclinical study reports that combining the CD44v6 inhibitor AMC303 with the dual PI3K/mTOR inhibitor Apitolisib suppresses HGF-driven reprogramming and ...
AI models fuse multi-omics data to predict immunotherapy response in cancer
A narrative review in Cancer Cell International outlines how artificial intelligence can integrate genomic, transcriptomic, imaging, and other multi-omics data ...
One Enzyme, Two Faces: ASRGL1 Emerges as a Context-Dependent Player in Cancer
A new review maps how the self-activating enzyme ASRGL1 shows pro-tumor activity in liver, cervical and prostate cancers while behaving ...
Editorial reviews multi-omics evidence on metastatic cancer ecosystems
An editorial reviewing 15 studies finds that single-cell, spatial, metabolic, epigenetic and imaging methods expose cellular ecosystems associated with metastatic ...
TCGA study links coagulation-associated lncRNAs to prostate cancer prognosis
A TCGA-based prostate cancer study developed a coagulation-associated lncRNA prognostic signature, found distinct immune-related features in high-risk patients, and showed ...
Preclinical ginsenoside evidence points to multiple liver-cancer mechanisms
A review of 86 cellular, animal and clinical studies reports multiple antitumor mechanisms for ginsenosides in liver-cancer models, while noting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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