T cells in AML are not uniformly dysfunctional, researchers argue in new analysis
A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...
Tag: tumor microenvironment
Schwann Cells Rewired by Tumors May Shape Nerve Invasion and Immune Responses
A new review describes how tumors reprogram Schwann cells into states linked to perineural invasion, matrix remodeling and altered immune-cell ...
Recombinant HPV16 E7 vaccine plus CD137 agonism clears tumors in mice
A recombinant overlapping peptide vaccine targeting HPV16 E7, combined with 4-1BB agonist antibody, eradicated established tumors in most treated mice ...
Gut microbes may decide who responds to lung cancer immunotherapy
A new review maps how gut bacteria and their metabolites remotely reprogram lung tumors to shape immunotherapy response, resistance and ...
Biomaterials Target Cholesterol Metabolism to Exploit Cancer Cell Vulnerabilities
A new review maps how biomaterials can exploit cholesterol metabolism in cancer while warning that most mechanistic claims remain unproven.
Ageing extracellular matrix emerges as a hidden variable in 3D cancer models
A new review in Materials Today Bio argues that the age of the extracellular matrix is an overlooked variable in ...
Cancer Stem Cells, Immune Evasion and Vascularization Drive Therapy Resistance in Brain Tumors
A new review in the Journal of Translational Medicine examines how cancer stem cells, vascularization and immune evasion contribute to ...
Machine Learning Maps R-Loop Scores to NCL-Driven Malignant Progression in Colorectal Cancer
A consensus machine learning approach integrating single-cell and spatial transcriptomics identifies nucleolin (NCL) as a functional marker of R-loop-associated malignant ...
Tumor cell program tied to lymphatic responses in aggressive thyroid cancer
A multi-omics study links an extracellular matrix-associated epithelial state and a SERPINA1–SOX4–FN1 molecular axis to lymphatic endothelial responses in papillary ...
Extracellular vesicles emerge as dual players in tumor immunity and drug resistance
A new editorial argues that extracellular vesicles both drive tumor adaptation and drug resistance and offer promising platforms for antitumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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