PLPP4 marks a fibroblast subset that fuels tumor growth through excess matrix deposition
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
Tag: tumor microenvironment
Immune-cell study hints IL-1β macrophages may fuel pro-tumor signals in liver cancer
Single-cell and multi-omics analyses of hepatocellular carcinoma point to IL-1β-positive macrophages and IL-1R1-positive inflammatory fibroblasts as putative drivers of a ...
Tumor acidity emerges as a metabolic barrier blocking cancer immunotherapy
A narrative review argues that the acidic tumor microenvironment suppresses antitumor immunity and that targeting acidity is a preclinically supported ...
Immunotherapy plus chemotherapy shows durable responses in lymph-node-dominant metastatic gallbladder cancer
A retrospective Chinese study reports that all 11 patients with lymph-node-dominant metastatic gallbladder cancer responded to PD-1 blockade plus gemcitabine ...
Blocking immune cell lipid signals may contain glioblastoma before surgery
VIB-KU Leuven researchers report that blocking lipid signals from brain immune cells made glioblastoma less invasive in mouse models and ...
Multimodal AI maps the path to personalized cancer immunotherapy
A Science Bulletin review outlines how multimodal artificial intelligence integrating molecular, cellular, and clinical data could refine immunotherapy decisions while ...
Copper-Driven Cell Death Offers a New Angle on Triple-Negative Breast Cancer
A new review outlines how the copper-dependent cell death regulator FDX1 may shape prognosis, metabolism, and treatment resistance in triple-negative ...
Tumor microbes, immune cells and metabolites track CEA levels in colorectal cancer
A multi-omics study of 63 colorectal tumors links higher bacterial richness, specific anaerobic taxa, myeloid immune infiltration and the metabolite ...
Chemokine CXCL1/8-CXCR1/2 axis drives inflammatory niche in NF1 tumors
A new study identifies the CXCL1/8-CXCR1/2 chemokine axis as a driver of the inflammatory tumor microenvironment and matrix remodeling in ...
Marine Microbial Arginase Emerges as a Candidate for Arginine-Depriving Cancer Therapy
A new review in Medical Oncology examines marine microbial arginase as a stable enzyme platform for arginine deprivation therapy against ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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