HAT1 Emerges as a Driver of Glioblastoma Growth and Drug Sensitivity
A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...
Tag: tumor microenvironment
MEK inhibitor cobimetinib reshapes tumor-fibroblast crosstalk in preclinical anaplastic thyroid carcinoma models
A preclinical study reports that the MEK inhibitor cobimetinib suppressed MAPK signaling, tumor cell invasion and immune-evasive features in anaplastic ...
RNA positions in the breast tumor microenvironment linked to DCIS progression and recurrence
A study of breast tissue microarrays mapped where regulatory RNAs and stromal proteins sit within benign, DCIS and invasive lesions, ...
How Regulatory T Cells Help Ovarian Cancer Hide From the Immune System
A new review explains how regulatory T cells are co-opted by ovarian tumors to suppress immunity, and how precision therapies ...
Single-cell map reveals how EV-derived miRNAs shape the liver cancer microenvironment
A computational analysis of single-cell RNA sequencing data maps 208 prognosis-linked miRNA-target pairs carried by extracellular vesicles in the hepatocellular ...
Prostate Tumors in Hispanic American Men Show Distinct Molecular and Immune Features
A retrospective study of 83 men with metastatic hormone-sensitive prostate cancer found that Hispanic American patients presented with more advanced ...
CT-Derived Extracellular Volume Fraction Emerges as a Quantitative Biomarker for Abdominal Disease
A new review finds that CT-derived extracellular volume fraction correlates with fibrosis, tumor biology, prognosis, and treatment response across abdominal ...
Three-Gene Signature Tied to Tumor Purity Predicts Survival in Pancreatic Cancer
A three-gene signature linked to tumor purity stratifies pancreatic adenocarcinoma patients by survival and reveals differences in CD8-positive T-cell activation.
Machine Learning Model Links Tumor Cell Malignancy to Osteosarcoma Outcomes and Flags OPN3 as a Drug Target Candidate
A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...
AhR blockade rewires myeloid–T cell crosstalk and boosts anti-PD-1 response in preclinical tumor models
Preclinical research shows that blocking the aryl hydrocarbon receptor reshapes myeloid–T cell crosstalk and enhances anti-PD-1 responses across mouse and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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