Tag: TLR4

A systematic review of six observational studies in 131,568 sepsis patients identifies patient, disease, and treatment-related factors linked to stress ...

SR-A1 cooperates with TLR4 signaling in macrophages to drive TGF-β1 production, inducing regulatory T cells that reduce liver damage during ...

A new study reports that lncR-AK158273 suppresses microglial autophagy during LPS-induced neuroinflammation by upregulating Mst1 expression.

In rat bone marrow stem cells, the TLR4 inhibitor TAK-242 suppressed LPS-induced inflammatory gene expression while leaving osteogenic differentiation largely ...

Researchers identified the TLR2/TLR4-binding sequences of the matrix protein biglycan and showed that synthetic peptides carrying these motifs reduce inflammation ...

Scientists have computationally designed a multi-epitope chimeric vaccine candidate against Taenia tapeworms in livestock, with all results so far limited ...

A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...

In a rat study, lowering the protein Fetuin-A with pioglitazone was accompanied by reduced hippocampal neuroinflammation and recovered recognition memory ...

Researchers report a fully computational mRNA multi-epitope vaccine candidate, PV-GNProtecta, targeting conserved regions of the Puumala virus glycoprotein and nucleoprotein.

A new mini-review proposes that persistent microbial sensing through pattern recognition receptors may bridge acute infection and long-lasting pain.