Tag: TGF-beta

Single-cell and spatial analyses of human bone marrow reveal that clonal hematopoiesis of indeterminate potential is marked by fibroblast expansion, ...

A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...

New research shows the antimalarial derivative Artemotil suppresses STC1-driven TGF-beta/SMAD2/3 signalling to reduce fibrotic cartilage remodelling in osteoarthritis models.

A new study shows that sophocarpine, an alkaloid from Sophora flavescens, reduces subretinal fibrosis in mice by blocking TGF-β–driven epithelial-mesenchymal ...

Deleting the RNA splicing factor PTBP1 in cardiac fibroblasts reshapes the profibrotic response by altering alternative splicing of key fibrosis-related ...

A new review maps how secreted protein circuits in gastrointestinal tumours govern immune recruitment, suppression and response to checkpoint immunotherapy.

New research in Cell Death Discovery examines how aerobic glycolysis supports TGF-β-induced epithelial-to-mesenchymal transition in lung epithelial cells.

A new review in Molecular Cancer redefines the abscopal effect with strict diagnostic criteria and maps the immunological steps needed ...

Researchers identified novel PRSS1 trypsinogen variants in IgG4-related disease tissue and linked them to M2 macrophage-driven type 2 immune responses.

A short membrane-binding helix within the enamel protein ameloblastin has been shown to direct the polarity of enamel-forming cells and ...