KRAS Blockade Paired with CTLA-4 Therapy Cracks Gastric Cancer Immune Shield
A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...
Tag: TGF-beta
Stiff Tissue, Sick Tissue: How Mechanics May Drive Endometriosis and Adenomyosis
A new review in Reproductive Sciences proposes that tissue stiffness and mechanotransduction pathways may help explain the heterogeneity and progression ...
Epigenetic Aging Clocks Reveal How Stroke Accelerates Cognitive Decline
A large longitudinal study shows that DNA methylation-based biological aging and the cytokine TGF-beta play distinct causal roles in cognitive ...
Scientists Reveal the Cellular Dialogue That Scars Nasal Polyps From Within
A new study integrates single-cell transcriptomics with human tissue and mouse model validation to show that TGF-beta/Smad-driven dialogue between epithelial ...
New Antibody Targets BAMBI to Rewire Immune Cells in Psoriatic Arthritis
Spanish researchers have developed a humanized monoclonal antibody, hB101.37, that inhibits the BAMBI pseudoreceptor and rebalances T cell immunity, showing ...
The Hidden Architects of Colorectal Cancer: How Fibroblasts Drive Treatment Failure
A new review in Cancer Cell International details how cancer-associated fibroblasts remodel the colorectal tumor microenvironment and drive resistance to ...
Hedgehog-Responsive Perivascular Cells Emerge as Master Switches of Blood Vessel Repair and Disease
A new review synthesizes a decade of evidence showing that GLI1-positive perivascular cells act as state-dependent regulators of angiogenesis, capable ...
Feverfew Compound Parthenolide Eases Skin Fibrosis by Stabilizing Mitochondria-ER Contacts
A new study shows that parthenolide, a compound from feverfew, alleviates cellular senescence and skin fibrosis in localized scleroderma by ...
Aging Hormone Signal Reveals Hidden Trigger of Age-Related Hearing Loss
New research in Aging Cell reveals that age-related decline in IGF-1 disables a mitochondrial protein in cochlear pericytes, triggering TGF-beta/Smad2-driven ...
Autophagy’s Double-Edged Role in Womb Scarring and Age-Related Fertility Decline
A new review in Reproductive Sciences argues that autophagy, the cell's recycling machinery, plays a context-dependent dual role in endometrial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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