How Chronic Alcohol Disables the Lung’s Sodium Pumps and Worsens ARDS
New research reveals the integrin αvβ6/TGF-β1/Smad4 signaling pathway as the molecular link between chronic alcohol consumption and impaired alveolar fluid ...
Tag: TGF-beta
UChicago Medicine Trials Homegrown Engineered T-Cell Therapy for Advanced Solid Tumors
UChicago Medicine has launched a first-of-its-kind investigator-initiated clinical trial of a fully on-site manufactured T-cell receptor therapy engineered to target ...
Do Fungal Pathogens Exploit HLA-G-Mediated Immune Tolerance?
The distinction between classical and nonclassical major histocompatibility complex class I molecules helps explain why HLA-G occupies such a unique ...
Spatial Transcriptomics Maps the Cellular Battlefields of Fatal COVID-19 Lungs
A spatial transcriptomics study of fatal COVID-19 lungs reveals progressive loss of endothelial and immune cells, explosive peribronchial fibroblast expansion, ...
Antifibrotic Drug Pirfenidone Cuts Lung Injury Risk in Immunotherapy-Treated Lung Cancer Patients
A phase II trial found that prophylactic pirfenidone significantly reduced grade 2 or higher radiation-induced lung injury in lung cancer ...
Regulatory Immune Cells Rise With Lung Cancer Severity, Blood Study Finds
A prospective case-control study reports that circulating regulatory B cells, regulatory T cells, and a broad serum cytokine panel are ...
Dead Probiotic Cells Show Promise for Healing Infected Burn Wounds in Mice
A new mouse study shows that non-viable probiotic cells, or paraprobiotics, can suppress bacterial virulence factors and shift infected burn ...
Old Antibiotics, New Trick: Doxycycline Blocks Prostate Cancer Spread to Bone
Researchers report that the FDA-approved antibiotics doxycycline and methacycline selectively bind acetylated KLF5 and suppress prostate cancer bone metastasis by ...
Plant Terpenes May Rewire Ion Channels Linked to Diabetes and Fibrosis
A new review in Molecular Biology Reports argues that plant-derived terpenes and terpenoids may modulate TRPV ion channels to influence ...
Collagen Scaffold in Tumors Primes Colorectal Cancer Cells to Evade Chemotherapy
Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!