Aging Hormone Signal Reveals Hidden Trigger of Age-Related Hearing Loss
New research in Aging Cell reveals that age-related decline in IGF-1 disables a mitochondrial protein in cochlear pericytes, triggering TGF-beta/Smad2-driven ...
Tag: TGF-beta
Autophagy’s Double-Edged Role in Womb Scarring and Age-Related Fertility Decline
A new review in Reproductive Sciences argues that autophagy, the cell's recycling machinery, plays a context-dependent dual role in endometrial ...
Hidden Scars in the Bone Marrow: Clonal Hematopoiesis Rewrites the Niche Before Cancer Strikes
Single-cell and spatial analyses of human bone marrow reveal that clonal hematopoiesis of indeterminate potential is marked by fibroblast expansion, ...
Scientists Uncover Hidden Feedback Loop That Drives Colon Cancer Spread
A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...
Antimalarial Drug Artemotil Shows Promise Against Cartilage Scarring in Osteoarthritis
New research shows the antimalarial derivative Artemotil suppresses STC1-driven TGF-beta/SMAD2/3 signalling to reduce fibrotic cartilage remodelling in osteoarthritis models.
Traditional Medicine Alkaloid Sophocarpine Shows Promise Against Blinding Retinal Scarring
A new study shows that sophocarpine, an alkaloid from Sophora flavescens, reduces subretinal fibrosis in mice by blocking TGF-β–driven epithelial-mesenchymal ...
Loss of a Single Splicing Protein Reshapes the Heart’s Scarring Response
Deleting the RNA splicing factor PTBP1 in cardiac fibroblasts reshapes the profibrotic response by altering alternative splicing of key fibrosis-related ...
Hidden Protein Signals Decide Why Immunotherapy Fails in Gut Cancers
A new review maps how secreted protein circuits in gastrointestinal tumours govern immune recruitment, suppression and response to checkpoint immunotherapy.
Aerobic Glycolysis Emerges as a Key Driver of TGF-β-Induced EMT in Lung Cells
New research in Cell Death Discovery examines how aerobic glycolysis supports TGF-β-induced epithelial-to-mesenchymal transition in lung epithelial cells.
Scientists Map How Local Cancer Therapy Can Reroute the Entire Immune System
A new review in Molecular Cancer redefines the abscopal effect with strict diagnostic criteria and maps the immunological steps needed ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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