Landmark Study Reveals How Cellular Recycling Falters in Parkinson’s Disease
A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...
Tag: SUMOylation
Hidden Immune Brake Found to Keep Gut Inflammation in Check
Researchers report that the transcription factor Zbtb44, through SUMOylation-dependent interaction with T-bet, represses interferon-gamma production by T cells and thereby ...
Sticky Tags on a Viral Enzyme: SUMOylation Steers Herpesvirus Thymidine Kinase Into Neurons
Researchers report that SUMOylation of pseudorabies virus thymidine kinase at two lysine residues controls the enzyme's nuclear localization, enabling efficient ...
Scientists Uncover Molecular Switch That Helps Prostate Cancer Spread to Bone
A new study reveals that an AURKA-driven phosphorylation and SUMOylation cascade stabilizes the protein SPICE1, fueling prostate cancer's spread to ...
Molecular Off Switch: Enzyme That Strips SUMO Tags Decides When Arabidopsis Seeds Wake Up
A new study shows that the SUMO protease ASP1 removes regulatory tags from the chromatin protein AL6, promoting its degradation ...
Chemical Tags on Tiny Vesicles May Shape How Cancer Spreads
A new review in the Journal of Translational Medicine details how post-translational modifications such as ubiquitination, phosphorylation, acetylation, and SUMOylation ...
Oncogenic viruses hijack a lysosomal receptor to fuel cancer growth
A new Nature Microbiology study shows that oncogenic viruses hijack chaperone-mediated autophagy by inducing TRIM32-mediated SUMOylation of LAMP2A, promoting viral ...
Cell Study Reveals How TRIM28 Fires Up Inflammatory Macrophages to Drive Keratinocyte Overgrowth
New laboratory research shows that the protein TRIM28 drives macrophages toward a pro-inflammatory state through the NLRP3/SGT1 axis and SUMOylation, ...
Cancer Reshapes the SUMOylation Landscape to Sabotage Muscle Function, Study Finds
New research reveals that cancer reorganizes the SUMOylation landscape in skeletal muscle and alters L3mbtl2-mediated transcriptional control, offering a molecular ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!