Newly isolated feline coronavirus strain AH2023 proves lethal in cats
Researchers in China isolated the recombinant feline coronavirus type II strain AH2023, which proved uniformly lethal in experimentally infected young ...
Tag: spike protein
Synthetic Sulfolipid Reshapes Dendritic Cell Response to SARS-CoV-2 Spike Protein in Lab Model
In vitro experiments show the synthetic sulfolipid Sulfavant A curbs spike-protein-driven IL-6 and TNF-alpha release in human dendritic cells while ...
SARS-CoV-2 Spike Protein Competes with ENaC for Plasmin Cleavage, Driving Pulmonary Edema
A new study reports that the SARS-CoV-2 spike protein competitively inhibits plasmin-mediated cleavage of the epithelial sodium channel ENaC at ...
Cryo-EM reveals how Andes hantavirus grips its human cell receptor
A new Nature study shows that the Andes virus spike captures the PCDH1 receptor through a deep central pocket that ...
Receptor promiscuity in bat sarbecoviruses exposes conserved spike targets
Two new PLOS Biology studies link broad ACE2 receptor use in bat sarbecoviruses to shared spike epitopes that human antibodies ...
Hydrophobic loop remodeling weakens ACE2 binding in SARS-CoV-2 JN.4
Cryo-EM and functional assays show that the JN.4-specific A475V substitution remodels the SARS-CoV-2 RBD large loop and reduces ACE2-binding affinity ...
Three African natural products disrupt SARS-CoV-2 entry and replication in vitro
A laboratory screen found that three African natural-product compounds disrupted SARS-CoV-2 spike–ACE2 interactions, while two also reduced viral replication in ...
Lingering Viral Spike Protein Found in the Lungs of Long COVID Patients
Bronchoalveolar lavage analysis reveals three distinct inflammatory phenotypes in post-COVID-19 lung disease and persistent SARS-CoV-2 spike protein up to two ...
Booster Vaccine Platform Shapes the Breadth and Durability of SARS-CoV-2 T-Cell Immunity
A nine-month Ghanaian cohort study finds that adenoviral-vector boosting sustains broader and more durable SARS-CoV-2 T-cell epitope recognition than mRNA ...
Sandwich ELISA Offers Rapid Antigen Test for Feline Coronavirus Detection
Researchers in China have developed a double-antibody sandwich ELISA that detects the feline coronavirus spike protein in faecal samples with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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