Single-Cell Atlas Reveals How the Metabolic Enzyme PDK4 Drives Scarring After Heart Attack
A single-cell atlas of nearly a quarter-million cardiac fibroblasts reveals eight distinct cell populations and identifies the metabolic enzyme PDK4 ...
Tag: single-cell transcriptomics
New computational benchmark reveals how closely lab-grown embryo models match real human development
University of Sydney researchers have created a computational framework that benchmarks stem-cell-derived blastoid models against a comprehensive single-cell reference map ...
Beyond M1 and M2: Rethinking How the NIK Enzyme Drives Retinal Damage in Diabetes
A new commentary argues that the kinase NIK reshapes disease-associated microglial states in diabetic retinopathy rather than simply flipping a ...
The Case of the Missing Mouse Pax6 Neuron: A Cross-Species Mix-Up Rewrites Brain Cell Taxonomy
A cross-species transcriptomic meta-analysis reveals that the mouse Pax6 interneuron subclass was never missing but mislabeled, while the primate Sncg ...
Inside the Cellular Storm: Single-Cell Map Reveals How Coral Bleaching Really Unfolds
A single-cell transcriptomic study of the coral Orbicella faveolata reveals cell-type-specific and microbiome-wide dynamics that drive the breakdown of the ...
Common ‘Forever Chemical’ PFOS Linked to Immune-Metabolic Disruption in Fatty Liver Disease
An integrated study combining NHANES epidemiology, machine learning, single-cell transcriptomics, molecular docking, and mouse experiments links background-level PFOS exposure to ...
ParTIpy Brings Pareto Task Inference to Million-Cell Single-Cell Datasets
An open-source Python package called ParTIpy scales archetypal analysis and Pareto task inference to millions of single cells, offering a ...
Label-Free Raman Imaging Joins Transcriptomics to Map Senescence in Aging Tissue
Researchers have introduced RamanOmics, a label-free strategy combining Raman imaging with spatial and single-cell transcriptomics to map a lipid-linked vibrational ...
New Sequencing Method Maps RNA Isoforms Across Brain Cells With Single-Cell Precision
A new Nature Methods study introduces spatial isoform sequencing tools that reveal cell-type-specific RNA isoform variability across mouse brain tissue ...
Human and Mouse Adrenal Glands Follow Surprisingly Different Rules of Hormone Production and Renewal
A new single-cell and spatial transcriptomic atlas reveals that human and mouse adrenal glands differ in their steroid-producing cell states ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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